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Literature summary extracted from

  • Bergman, A.C.; Nyman, P.O.; Larsson, G.
    Kinetic properties and stereospecificity of the monomeric dUTPase from herpes simplex virus type 1 (1998), FEBS Lett., 441, 327-330.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.23 dCTP
-
 Human alphaherpesvirus 1
3.6.1.23 dTTP
-
 Human alphaherpesvirus 1
3.6.1.23 dUDP
-
 Human alphaherpesvirus 1
3.6.1.23 dUMP alphaS
-
 Human alphaherpesvirus 1
3.6.1.23 dUTPalphaS
-
 Human alphaherpesvirus 1
3.6.1.23 UDP
-
 Human alphaherpesvirus 1
3.6.1.23 Uracil
-
 Human alphaherpesvirus 1

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.23 0.0002
-
 dUTPalphaS
-
 Human alphaherpesvirus 1
3.6.1.23 0.0003
-
 dUTP
-
 Human alphaherpesvirus 1
3.6.1.23 0.4
-
 dTTP
-
 Human alphaherpesvirus 1
3.6.1.23 1
-
 UTP
-
 Human alphaherpesvirus 1
3.6.1.23 1
-
 dCTP
-
 Human alphaherpesvirus 1

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Human alphaherpesvirus 1
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dCTP + H2O
-
 Human alphaherpesvirus 1 dCMP + diphosphate
-
 ?
3.6.1.23 dTTP + H2O
-
 Human alphaherpesvirus 1 dTMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O
-
 Human alphaherpesvirus 1 dUMP + diphosphate
-
 ?
3.6.1.23 dUTPalphaS + H2O
-
 Human alphaherpesvirus 1 dUMP + thiodiphosphate
-
 ?
3.6.1.23 UTP + H2O
-
 Human alphaherpesvirus 1 UMP + diphosphate
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6.1.23 5 15 dUTP
-
 Human alphaherpesvirus 1

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.6.1.23 6 9 stable for several h Human alphaherpesvirus 1