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Literature summary extracted from
- Ecdysone 20-monooxygenase in eggs of the silkworm, Bombyx mori: enzymatic properties and developmental changes (1999), Arch. Insect Biochem. Physiol., 41, 9-17.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.22 | KK-42 | i.e. 1-benzyl-5[(E)-2,6-dimethyl-1,5-heptadienyl]imidazole | Bombyx mori |  |
| 1.14.99.22 | Metyrapone | - |
Bombyx mori | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.99.22 | microsome | - |
Bombyx mori | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.22 | ecdysone + NADPH + O2 | Bombyx mori | - |
20-hydroxyecdysone + NADP+ + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.22 | Bombyx mori | - |
silkworm | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.14.99.22 | ecdysone + reduced acceptor + O2 = 20-hydroxyecdysone + acceptor + H2O | NADPH-dependent monooxygenase containing cytochrome P-450, a heme-thiolate protein | Bombyx mori |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.99.22 | additional information | enzyme activity measured in diapause and non-diapause egg subcellular preparations | Bombyx mori | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.22 | alpha-ecdysone + NADPH + O2 | - |
Bombyx mori | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
| 1.14.99.22 | ecdysone + NADPH + O2 | - |
Bombyx mori | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.22 | 35 | - |
- |
Bombyx mori |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.22 | 7.5 | - |
- |
Bombyx mori |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.22 | 6 | 8.5 | - |
Bombyx mori |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.22 | cytochrome P450 | essential | Bombyx mori | |
| 1.14.99.22 | NADPH | - |
Bombyx mori | |
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