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Literature summary extracted from

  • Suda, T.; Robinson, J.C.; Fjellstedt, T.A.
    Purification and properties of alpha-ketoadipate reductase, a newly discovered enzyme from human placenta (1976), Arch. Biochem. Biophys., 176, 610-620.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.172 NADH uncompetitive inhibition at high concentrations Homo sapiens
1.1.1.172 oxalate 10% inhibition at 0.5 mM Homo sapiens
1.1.1.172 p-chloromercuribenzoate slight inhibition at 0.02 mM, combined with 0.26 mM SDS Homo sapiens
1.1.1.172 SDS slight inhibition at 0.26 mM, combined with 0.02 mM p-chloromercuribenzoate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.172 0.011
-
NADH
-
Homo sapiens
1.1.1.172 2.6
-
2-oxoadipate
-
Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.172 95000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.172 2-oxoadipate + NADH Homo sapiens highly specific 2-hydroxyadipate + NAD+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.172 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.172 near homogeneity, chromatography techniques, electrofocusing Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.172 placenta
-
Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
1.1.1.172 4°C, 25 mM potassium phosphate, pH 7.5, 20% glycerol, no decrease of activity for several months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.172 2-oxoadipate + NADH highly specific Homo sapiens 2-hydroxyadipate + NAD+
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.172 NADH
-
Homo sapiens