EC Number | Application | Comment | Organism |
---|---|---|---|
1.1.1.45 | medicine | role in an alternative pathway of the production of xylitol in the lens that causes cataracts in mammalian organisms | Rattus norvegicus |
1.1.1.45 | medicine | role in an alternative pathway of the production of xylitol in the lens that causes cataracts in mammalian organisms | Bos taurus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.19 | barbiturates | - |
Bos taurus | |
1.1.1.19 | Diphenylhydantoin | - |
Bos taurus | |
1.1.1.19 | N-ethylmaleimide | no exact differentiation between organisms in the reference | Bos taurus | |
1.1.1.19 | N-ethylmaleimide | no exact differentiation between organisms in the reference | Rattus norvegicus | |
1.1.1.19 | p-chloromercuribenzoate | no exact differentiation between organisms in the reference | Bos taurus | |
1.1.1.19 | p-chloromercuribenzoate | no exact differentiation between organisms in the reference | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.19 | 0.0543 | - |
D-glucuronate | no exact differentiation between organisms in the reference | Rattus norvegicus | |
1.1.1.19 | 0.0543 | - |
D-glucuronate | no exact differentiation between organisms in the reference | Bos taurus | |
1.1.1.19 | 0.0543 | - |
D-glucuronate | defined as D-glucuronate reductase | Rattus norvegicus | |
1.1.1.19 | 0.0543 | - |
D-glucuronate | defined as D-glucuronate reductase | Bos taurus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.19 | 36000 | - |
2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference | Rattus norvegicus |
1.1.1.19 | 36000 | - |
2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference | Bos taurus |
1.1.1.19 | 60000 | 70000 | no exact differentiation between organisms in the reference, gel filtration | Rattus norvegicus |
1.1.1.19 | 60000 | 70000 | no exact differentiation between organisms in the reference, gel filtration | Bos taurus |
1.1.1.45 | 60000 | 70000 | HPLC gel filtration | Rattus norvegicus |
1.1.1.45 | 60000 | 70000 | HPLC gel filtration | Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.19 | D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
1.1.1.19 | D-glucuronate + NADPH | Rattus norvegicus | - |
L-gulonate + NADP+ | - |
r | |
1.1.1.19 | D-glucuronate + NADPH | Bos taurus | - |
L-gulonate + NADP+ | - |
r | |
1.1.1.19 | L-gulonate + NADP+ | Homo sapiens | - |
D-glucuronate + NADPH | - |
r | |
1.1.1.19 | L-gulonate + NADP+ | Rattus norvegicus | - |
D-glucuronate + NADPH | - |
r | |
1.1.1.19 | L-gulonate + NADP+ | Bos taurus | - |
D-glucuronate + NADPH | - |
r | |
1.1.1.45 | L-gulonic acid + NAD+ | Rattus norvegicus | glucuronate-xylulose cycle | 3-dehydro-L-gulonic acid + NADH + H+ | - |
? | |
1.1.1.45 | L-gulonic acid + NAD+ | Bos taurus | glucuronate-xylulose cycle | 3-dehydro-L-gulonic acid + NADH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.19 | Bos taurus | - |
- |
- |
1.1.1.19 | Homo sapiens | - |
- |
- |
1.1.1.19 | Rattus norvegicus | - |
- |
- |
1.1.1.45 | Bos taurus | - |
- |
- |
1.1.1.45 | Rattus norvegicus | - |
rat | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.19 | no exact differentiation between organisms in the reference | Rattus norvegicus |
1.1.1.19 | no exact differentiation between organisms in the reference | Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.19 | lens | - |
Homo sapiens | - |
1.1.1.19 | lens | - |
Rattus norvegicus | - |
1.1.1.19 | lens | - |
Bos taurus | - |
1.1.1.45 | lens | - |
Rattus norvegicus | - |
1.1.1.45 | lens | - |
Bos taurus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.19 | 0.0025 | - |
substrate D-glucuronate, defined as D-glucuronate reductase | Rattus norvegicus |
1.1.1.19 | 0.0025 | - |
substrate D-glucuronate, defined as D-glucuronate reductase | Bos taurus |
1.1.1.19 | 0.0025 | - |
no exact differentiation between organisms in the reference | Rattus norvegicus |
1.1.1.19 | 0.0025 | - |
no exact differentiation between organisms in the reference | Bos taurus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.19 | D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
1.1.1.19 | D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
1.1.1.19 | D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
r | |
1.1.1.19 | L-gulonate + NADP+ | - |
Homo sapiens | D-glucuronate + NADPH | - |
r | |
1.1.1.19 | L-gulonate + NADP+ | - |
Rattus norvegicus | D-glucuronate + NADPH | - |
r | |
1.1.1.19 | L-gulonate + NADP+ | - |
Bos taurus | D-glucuronate + NADPH | - |
r | |
1.1.1.45 | L-gulonic acid + NAD+ | - |
Rattus norvegicus | 3-dehydro-L-gulonic acid + NADH + H+ | - |
r | |
1.1.1.45 | L-gulonic acid + NAD+ | - |
Bos taurus | 3-dehydro-L-gulonic acid + NADH + H+ | - |
r | |
1.1.1.45 | L-gulonic acid + NAD+ | glucuronate-xylulose cycle | Rattus norvegicus | 3-dehydro-L-gulonic acid + NADH + H+ | - |
? | |
1.1.1.45 | L-gulonic acid + NAD+ | glucuronate-xylulose cycle | Bos taurus | 3-dehydro-L-gulonic acid + NADH + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.19 | dimer | 2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference | Rattus norvegicus |
1.1.1.19 | dimer | 2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference | Bos taurus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.19 | 38 | - |
no exact differentiation between organisms in the reference | Rattus norvegicus |
1.1.1.19 | 38 | - |
no exact differentiation between organisms in the reference | Bos taurus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.19 | 7.5 | - |
no exact differentiation between organisms in the reference | Rattus norvegicus |
1.1.1.19 | 7.5 | - |
no exact differentiation between organisms in the reference | Bos taurus |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.19 | 8 | - |
no exact differentiation between organisms in the reference | Rattus norvegicus |
1.1.1.19 | 8 | - |
no exact differentiation between organisms in the reference | Bos taurus |
1.1.1.19 | 8 | - |
rapid decrease of activity above pH 8.0 | Rattus norvegicus |
1.1.1.19 | 8 | - |
rapid decrease of activity above pH 8.0 | Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.19 | NADP+ | - |
Homo sapiens | |
1.1.1.19 | NADP+ | - |
Rattus norvegicus | |
1.1.1.19 | NADP+ | - |
Bos taurus | |
1.1.1.19 | NADPH | - |
Homo sapiens | |
1.1.1.19 | NADPH | - |
Rattus norvegicus | |
1.1.1.19 | NADPH | - |
Bos taurus | |
1.1.1.45 | NAD+ | - |
Rattus norvegicus | |
1.1.1.45 | NAD+ | - |
Bos taurus | |
1.1.1.45 | NADH | - |
Rattus norvegicus | |
1.1.1.45 | NADH | - |
Bos taurus |