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Literature summary extracted from

  • Goode, D.; Lewis, M.E.; Crabbe, M.J.C.
    Accumulation of xylitol in the mammalian lens is realted to glucoronate metabolism (1996), FEBS Lett., 395, 174-178.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.45 medicine role in an alternative pathway of the production of xylitol in the lens that causes cataracts in mammalian organisms Rattus norvegicus
1.1.1.45 medicine role in an alternative pathway of the production of xylitol in the lens that causes cataracts in mammalian organisms Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.19 barbiturates
-
Bos taurus
1.1.1.19 Diphenylhydantoin
-
Bos taurus
1.1.1.19 N-ethylmaleimide no exact differentiation between organisms in the reference Bos taurus
1.1.1.19 N-ethylmaleimide no exact differentiation between organisms in the reference Rattus norvegicus
1.1.1.19 p-chloromercuribenzoate no exact differentiation between organisms in the reference Bos taurus
1.1.1.19 p-chloromercuribenzoate no exact differentiation between organisms in the reference Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.19 0.0543
-
D-glucuronate no exact differentiation between organisms in the reference Rattus norvegicus
1.1.1.19 0.0543
-
D-glucuronate no exact differentiation between organisms in the reference Bos taurus
1.1.1.19 0.0543
-
D-glucuronate defined as D-glucuronate reductase Rattus norvegicus
1.1.1.19 0.0543
-
D-glucuronate defined as D-glucuronate reductase Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.19 36000
-
2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference Rattus norvegicus
1.1.1.19 36000
-
2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference Bos taurus
1.1.1.19 60000 70000 no exact differentiation between organisms in the reference, gel filtration Rattus norvegicus
1.1.1.19 60000 70000 no exact differentiation between organisms in the reference, gel filtration Bos taurus
1.1.1.45 60000 70000 HPLC gel filtration Rattus norvegicus
1.1.1.45 60000 70000 HPLC gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.19 D-glucuronate + NADPH Homo sapiens
-
L-gulonate + NADP+
-
r
1.1.1.19 D-glucuronate + NADPH Rattus norvegicus
-
L-gulonate + NADP+
-
r
1.1.1.19 D-glucuronate + NADPH Bos taurus
-
L-gulonate + NADP+
-
r
1.1.1.19 L-gulonate + NADP+ Homo sapiens
-
D-glucuronate + NADPH
-
r
1.1.1.19 L-gulonate + NADP+ Rattus norvegicus
-
D-glucuronate + NADPH
-
r
1.1.1.19 L-gulonate + NADP+ Bos taurus
-
D-glucuronate + NADPH
-
r
1.1.1.45 L-gulonic acid + NAD+ Rattus norvegicus glucuronate-xylulose cycle 3-dehydro-L-gulonic acid + NADH + H+
-
?
1.1.1.45 L-gulonic acid + NAD+ Bos taurus glucuronate-xylulose cycle 3-dehydro-L-gulonic acid + NADH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.19 Bos taurus
-
-
-
1.1.1.19 Homo sapiens
-
-
-
1.1.1.19 Rattus norvegicus
-
-
-
1.1.1.45 Bos taurus
-
-
-
1.1.1.45 Rattus norvegicus
-
rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.19 no exact differentiation between organisms in the reference Rattus norvegicus
1.1.1.19 no exact differentiation between organisms in the reference Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.19 lens
-
Homo sapiens
-
1.1.1.19 lens
-
Rattus norvegicus
-
1.1.1.19 lens
-
Bos taurus
-
1.1.1.45 lens
-
Rattus norvegicus
-
1.1.1.45 lens
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.19 0.0025
-
substrate D-glucuronate, defined as D-glucuronate reductase Rattus norvegicus
1.1.1.19 0.0025
-
substrate D-glucuronate, defined as D-glucuronate reductase Bos taurus
1.1.1.19 0.0025
-
no exact differentiation between organisms in the reference Rattus norvegicus
1.1.1.19 0.0025
-
no exact differentiation between organisms in the reference Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.19 D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
r
1.1.1.19 D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
r
1.1.1.19 D-glucuronate + NADPH
-
Bos taurus L-gulonate + NADP+
-
r
1.1.1.19 L-gulonate + NADP+
-
Homo sapiens D-glucuronate + NADPH
-
r
1.1.1.19 L-gulonate + NADP+
-
Rattus norvegicus D-glucuronate + NADPH
-
r
1.1.1.19 L-gulonate + NADP+
-
Bos taurus D-glucuronate + NADPH
-
r
1.1.1.45 L-gulonic acid + NAD+
-
Rattus norvegicus 3-dehydro-L-gulonic acid + NADH + H+
-
r
1.1.1.45 L-gulonic acid + NAD+
-
Bos taurus 3-dehydro-L-gulonic acid + NADH + H+
-
r
1.1.1.45 L-gulonic acid + NAD+ glucuronate-xylulose cycle Rattus norvegicus 3-dehydro-L-gulonic acid + NADH + H+
-
?
1.1.1.45 L-gulonic acid + NAD+ glucuronate-xylulose cycle Bos taurus 3-dehydro-L-gulonic acid + NADH + H+
-
?

Subunits

EC Number Subunits Comment Organism
1.1.1.19 dimer 2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference Rattus norvegicus
1.1.1.19 dimer 2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.19 38
-
no exact differentiation between organisms in the reference Rattus norvegicus
1.1.1.19 38
-
no exact differentiation between organisms in the reference Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.19 7.5
-
no exact differentiation between organisms in the reference Rattus norvegicus
1.1.1.19 7.5
-
no exact differentiation between organisms in the reference Bos taurus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.1.1.19 8
-
no exact differentiation between organisms in the reference Rattus norvegicus
1.1.1.19 8
-
no exact differentiation between organisms in the reference Bos taurus
1.1.1.19 8
-
rapid decrease of activity above pH 8.0 Rattus norvegicus
1.1.1.19 8
-
rapid decrease of activity above pH 8.0 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.19 NADP+
-
Homo sapiens
1.1.1.19 NADP+
-
Rattus norvegicus
1.1.1.19 NADP+
-
Bos taurus
1.1.1.19 NADPH
-
Homo sapiens
1.1.1.19 NADPH
-
Rattus norvegicus
1.1.1.19 NADPH
-
Bos taurus
1.1.1.45 NAD+
-
Rattus norvegicus
1.1.1.45 NAD+
-
Bos taurus
1.1.1.45 NADH
-
Rattus norvegicus
1.1.1.45 NADH
-
Bos taurus