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Literature summary extracted from

  • Barski, O.A.; Gabbay, K.H.; Grimshaw, C.E.; Bohren, K.M.
    Mechanism of human aldehyde reductase: characterization of the active site pocket (1995), Biochemistry, 34, 11264-11275.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 AL1576
-
 Homo sapiens
1.1.1.2 Alrestatin
-
 Homo sapiens
1.1.1.2 FK366
-
 Homo sapiens
1.1.1.2 ponalrestat
-
 Homo sapiens
1.1.1.2 Tolrestat
-
 Homo sapiens
1.1.1.2 zopolrestat
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.038
-
 p-Carboxybenzaldehyde wild-type aldehyde reductase Homo sapiens
1.1.1.2 0.1
-
 p-Carboxybenzaldehyde aldehyde reductase, mutant V299C Homo sapiens
1.1.1.2 0.16
-
 p-nitrobenzaldehyde wild-type aldehyde reductase Homo sapiens
1.1.1.2 0.17
-
 Succinic semialdehyde wild-type aldehyde reductase Homo sapiens
1.1.1.2 0.38
-
 p-nitrobenzaldehyde aldehyde reductase, mutant V299C Homo sapiens
1.1.1.2 0.38
-
 p-Carboxybenzaldehyde aldehyde reductase, mutant I298A Homo sapiens
1.1.1.2 0.41
-
 Succinic semialdehyde aldehyde reductase, mutant V299C Homo sapiens
1.1.1.2 0.43
-
 p-Carboxybenzaldehyde aldehyde reductase, mutant I298C Homo sapiens
1.1.1.2 1.2
-
 p-nitrobenzaldehyde aldehyde reductase, mutant I298C Homo sapiens
1.1.1.2 1.5
-
 Succinic semialdehyde aldehyde reductase, mutant I298C Homo sapiens
1.1.1.2 1.7
-
 DL-glyceraldehyde wild-type aldehyde reductase Homo sapiens
1.1.1.2 1.7
-
 DL-glyceraldehyde wild type enzyme, at pH 7.0 and 25°C Homo sapiens
1.1.1.2 1.8
-
 DL-glyceraldehyde aldehyde reductase, mutant V299C Homo sapiens
1.1.1.2 1.8
-
 DL-glyceraldehyde mutant enzyme V299C, at pH 7.0 and 25°C Homo sapiens
1.1.1.2 2.8
-
 Succinic semialdehyde aldehyde reductase, mutant I298A Homo sapiens
1.1.1.2 2.8
-
 p-nitrobenzaldehyde aldehyde reductase, mutant I298A Homo sapiens
1.1.1.2 2.8
-
 p-Carboxybenzaldehyde aldehyde reductase, mutant H112Q Homo sapiens
1.1.1.2 4.2
-
 D-glucuronate wild-type aldehyde reductase Homo sapiens
1.1.1.2 4.2
-
 D-glucuronate aldehyde reductase, mutant V299C Homo sapiens
1.1.1.2 5.9
-
 p-nitrobenzaldehyde aldehyde reductase, mutant H112Q Homo sapiens
1.1.1.2 11.5
-
 DL-glyceraldehyde aldehyde reductase, mutant I298C Homo sapiens
1.1.1.2 11.5
-
 DL-glyceraldehyde mutant enzyme I298C, at pH 7.0 and 25°C Homo sapiens
1.1.1.2 18
-
 Succinic semialdehyde aldehyde reductase, mutant H112Q Homo sapiens
1.1.1.2 19.5
-
 D-glucuronate aldehyde reductase, mutant I298C Homo sapiens
1.1.1.2 26.3
-
 D-glucuronate aldehyde reductase, mutant I298A Homo sapiens
1.1.1.2 33
-
 DL-glyceraldehyde aldehyde reductase, mutant I298A Homo sapiens
1.1.1.2 33
-
 DL-glyceraldehyde mutant enzyme I298A, at pH 7.0 and 25°C Homo sapiens
1.1.1.2 48
-
 D-glucuronate aldehyde reductase, mutant H112Q Homo sapiens
1.1.1.2 76
-
 DL-glyceraldehyde aldehyde reductase, mutant H112Q Homo sapiens
1.1.1.2 76
-
 DL-glyceraldehyde mutant enzyme H112Q, at pH 7.0 and 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Homo sapiens
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Homo sapiens
-
 glycerol + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Homo sapiens
-
 4-hydroxybutyrate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Homo sapiens
-
 human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2 wild-type aldehyde reductase and mutant A H112Q Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Homo sapiens p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Homo sapiens p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Homo sapiens 4-hydroxybutyrate + NADP+
-
 r

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.2 5.5 10
-
 Homo sapiens