Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cromlish, J.A.; Flynn, T.G.
    Purification and characterization of two aldose reductase isoenzymes from rabbit muscle (1983), J. Biol. Chem., 258, 3416-3424.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.21 (NH4)2SO4 0.1 M Rattus norvegicus
1.1.1.21 (NH4)2SO4 400 mM: activation Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 (NH4)2SO4 0.05 mM: slight inhibition, 400 mM: activation Oryctolagus cuniculus
1.1.1.21 (S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione
-
Oryctolagus cuniculus
1.1.1.21 (S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione
-
Rattus norvegicus
1.1.1.21 Alrestatin 1,3-dioxo-1H-benz[de]isoquinoline-2-(3H)acetic acid Oryctolagus cuniculus
1.1.1.21 Cu2+
-
Oryctolagus cuniculus
1.1.1.21 HgCl2
-
Bos taurus
1.1.1.21 HgCl2
-
Oryctolagus cuniculus
1.1.1.21 p-chloromercuribenzoate
-
Oryctolagus cuniculus
1.1.1.21 p-chloromercuribenzoate
-
Rattus norvegicus
1.1.1.21 quercetin
-
Oryctolagus cuniculus
1.1.1.21 Zn2+
-
Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.21 34000
-
gel filtration Oryctolagus cuniculus
1.1.1.21 40200
-
1 * 40200, aldose reductase 1, SDS-PAGE Oryctolagus cuniculus
1.1.1.21 41500
-
1 * 41500, aldose reductase 2, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.21 aldose + NAD(P)H Rattus norvegicus
-
alditol + NAD(P)+
-
r
1.1.1.21 aldose + NAD(P)H Sus scrofa
-
alditol + NAD(P)+
-
r
1.1.1.21 aldose + NAD(P)H Bos taurus
-
alditol + NAD(P)+
-
r
1.1.1.21 aldose + NAD(P)H Oryctolagus cuniculus
-
alditol + NAD(P)+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Bos taurus
-
-
-
1.1.1.21 Oryctolagus cuniculus
-
-
-
1.1.1.21 Rattus norvegicus
-
-
-
1.1.1.21 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.1.1.21 no glycoprotein
-
Rattus norvegicus
1.1.1.21 no glycoprotein
-
Sus scrofa
1.1.1.21 no glycoprotein
-
Bos taurus
1.1.1.21 no glycoprotein
-
Oryctolagus cuniculus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.21
-
Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
Rattus norvegicus
-
1.1.1.21 lens
-
Sus scrofa
-
1.1.1.21 lens
-
Bos taurus
-
1.1.1.21 skeletal muscle
-
Rattus norvegicus
-
1.1.1.21 skeletal muscle
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 4-nitrobenzaldehyde + NAD(P)H
-
Bos taurus 4-nitrobenzyl alcohol + NAD(P)+
-
?
1.1.1.21 4-nitrobenzaldehyde + NAD(P)H
-
Oryctolagus cuniculus 4-nitrobenzyl alcohol + NAD(P)+
-
?
1.1.1.21 alditol + NAD(P)+
-
Rattus norvegicus aldose + NAD(P)H
-
r
1.1.1.21 alditol + NAD(P)+
-
Sus scrofa aldose + NAD(P)H
-
r
1.1.1.21 alditol + NAD(P)+
-
Bos taurus aldose + NAD(P)H
-
r
1.1.1.21 alditol + NAD(P)+
-
Oryctolagus cuniculus aldose + NAD(P)H
-
r
1.1.1.21 aldose + NAD(P)H
-
Rattus norvegicus alditol + NAD(P)+
-
r
1.1.1.21 aldose + NAD(P)H
-
Sus scrofa alditol + NAD(P)+
-
r
1.1.1.21 aldose + NAD(P)H
-
Bos taurus alditol + NAD(P)+
-
r
1.1.1.21 aldose + NAD(P)H
-
Oryctolagus cuniculus alditol + NAD(P)+
-
r
1.1.1.21 D-glucose + NAD(P)H
-
Rattus norvegicus sorbitol + NAD(P)+
-
r
1.1.1.21 D-glucose + NAD(P)H
-
Bos taurus sorbitol + NAD(P)+
-
r
1.1.1.21 D-glucose + NAD(P)H
-
Oryctolagus cuniculus sorbitol + NAD(P)+
-
r
1.1.1.21 D-glucuronate + NAD(P)H
-
Rattus norvegicus ?
-
r
1.1.1.21 D-glucuronate + NAD(P)H
-
Bos taurus ?
-
r
1.1.1.21 D-glucuronate + NAD(P)H
-
Oryctolagus cuniculus ?
-
r
1.1.1.21 D-xylose + NAD(P)H
-
Rattus norvegicus xylitol + NAD(P)+
-
r
1.1.1.21 D-xylose + NAD(P)H
-
Bos taurus xylitol + NAD(P)+
-
r
1.1.1.21 D-xylose + NAD(P)H
-
Oryctolagus cuniculus xylitol + NAD(P)+
-
r
1.1.1.21 xylitol + NAD(P)+
-
Bos taurus D-xylose + NAD(P)H + H+
-
r
1.1.1.21 xylitol + NAD(P)+
-
Oryctolagus cuniculus D-xylose + NAD(P)H + H+
-
r

Subunits

EC Number Subunits Comment Organism
1.1.1.21 monomer
-
Rattus norvegicus
1.1.1.21 monomer 1 * 41500, aldose reductase 2, SDS-PAGE Bos taurus
1.1.1.21 monomer 1 * 40200, aldose reductase 1, SDS-PAGE Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.21 6.5 7
-
Oryctolagus cuniculus