Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Nishimura, C.; Yamaoka, T.; Mizutani, M.; Yamashita, K.; Akera, T.; Tanimoto, T.
    Purification and characterization of the recombinant human aldose reductase expressed in baculovirus system (1991), Biochim. Biophys. Acta, 1078, 171-178.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.21 expression in baculovirus system Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 (E,E)-5[2-methyl-3-phenyl-2-propenylidene-4-oxo-2-thioxo-3-thiazolidine]acetic acid recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 (S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 N-[[6-methoxy-5(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.21 0.004
-
 NADPH recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 0.018
-
 L-glyceraldehyde recombinant from baculovirus system with Spodoptera frugiperda cells Homo sapiens
1.1.1.21 3.53
-
 D-glucuronate recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 5.04
-
 D-xylose recombinant fron baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 43.3
-
 D-galactose recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 98.1
-
 D-glucose recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.21 36000
-
 ? * 36000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.21 expressed in baculovirus system Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 muscle
-
 Homo sapiens
-
1.1.1.21 retina
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 alditol + NAD(P)+
-
 Homo sapiens aldose + NAD(P)H
-
 r
1.1.1.21 aldose + NAD(P)H
-
 Homo sapiens alditol + NAD(P)+
-
 r
1.1.1.21 D-galactose + NAD(P)H
-
 Homo sapiens dulcitol + NAD(P)+
-
 r
1.1.1.21 D-glucose + NAD(P)H
-
 Homo sapiens sorbitol + NAD(P)+
-
 r
1.1.1.21 D-glucuronate + NAD(P)H
-
 Homo sapiens ?
-
 r
1.1.1.21 D-xylose + NAD(P)H
-
 Homo sapiens xylitol + NAD(P)+
-
 r
1.1.1.21 DL-glyceraldehyde + NAD(P)H
-
 Homo sapiens glycerol + NAD(P)+
-
 r
1.1.1.21 L-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.21 More ? * 36000, SDS-PAGE Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.21 0.418
-
 D-glucuronate recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 0.48
-
 D-glucose recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 0.525
-
 D-galactose recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 0.635
-
 D-xylose recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
1.1.1.21 0.673
-
 DL-glyceraldehyde recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens