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Literature summary extracted from

  • Erwin, A.L.; Gotschlich, E.C.
    Oxidation of D-lactate and L-lactate by Neisseria meningitidis: Purification and cloning of meningococcal D-lactate dehydrogenase (1993), J. Bacteriol., 175, 6382-6391.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.28 expression in Escherichia coli Neisseria meningitidis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.28 CoCl2
-
 Neisseria meningitidis
1.1.1.28 Cu2+
-
 Neisseria meningitidis
1.1.1.28 D-malate
-
 Neisseria meningitidis
1.1.1.28 D-Tartrate
-
 Neisseria meningitidis
1.1.1.28 MnCl2
-
 Neisseria meningitidis
1.1.1.28 NiCl2
-
 Neisseria meningitidis
1.1.1.28 oxamate
-
 Neisseria meningitidis
1.1.1.28 pyruvate
-
 Neisseria meningitidis
1.1.1.28 ZnCl2
-
 Neisseria meningitidis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.28 0.59
-
 (R)-lactate
-
 Neisseria meningitidis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.28 plasma membrane spheroplast membrane Neisseria meningitidis 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.28 Ca2+
-
 Neisseria meningitidis
1.1.1.28 Mg2+
-
 Neisseria meningitidis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.28 70000
-
 SDS-PAGE Neisseria meningitidis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.28 (R)-lactate + NAD+ Neisseria meningitidis
-
 pyruvate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.28 Neisseria meningitidis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.28
-
 Neisseria meningitidis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.28 (R)-lactate + NAD+
-
 Neisseria meningitidis pyruvate + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.28 8
-
-
 Neisseria meningitidis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.28 NAD+
-
 Neisseria meningitidis
1.1.1.28 NADH
-
 Neisseria meningitidis