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Literature summary extracted from

  • Phelps, D.C.; Hatefi, Y.
    Inhibition of D(-)-beta-hydroxybutyrate dehydrogenase by modifiers of disulfides, thiols, and vicinal dithiols (1981), Biochemistry, 20, 453-458.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.30 phosphatidylcholine
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.30 diazenedicarboxylic acid bis(dimethylamide) NAD+ protects against inhibition Bos taurus
1.1.1.30 N-ethylmaleimide NAD+ protects against inhibition Bos taurus
1.1.1.30 p-chloromercuribenzoate 0.001 mM, extremely rapid inhibition, NAD+ and NADH protect against inhibition Bos taurus
1.1.1.30 Phenylarsine oxide NAD+ and NADH protect against inhibition Bos taurus
1.1.1.30 Sodium sulfide competitive vs. beta-hydroxybutyrate Bos taurus
1.1.1.30 sodium sulfite uncompetitive vs. NAD+ and acetoacetate, competitive vs. beta-hydroxybutyrate Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.30 0.08
-
 NADH
-
 Bos taurus
1.1.1.30 0.175
-
 NAD+
-
 Bos taurus
1.1.1.30 0.26
-
 acetoacetate
-
 Bos taurus
1.1.1.30 0.8
-
 (R)-3-hydroxybutanoate
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.30 mitochondrion
-
 Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.30 (R)-3-hydroxybutanoate + NAD+ Bos taurus
-
 acetoacetate + NADH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.30 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.30 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.30 (R)-3-hydroxybutanoate + NAD+
-
 Bos taurus acetoacetate + NADH
-
 r
1.1.1.30 (R)-3-hydroxybutanoate + NAD+
-
 Bos taurus acetoacetate + NADH + H+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.30 NAD+
-
 Bos taurus