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Literature summary extracted from
- Prevention of cold inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by NADPH (1975), Biochim. Biophys. Acta, 388, 254-259.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.34 | microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | Rattus norvegicus | - |
(R)-mevalonate + CoA + NADP+ | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.34 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 0.0147 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Rattus norvegicus | (R)-mevalonate + CoA + NADP+ | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 19 | - |
below 19°C reversible inactivation of enzyme activity, prevented by NADPH and NADP+ | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.34 | NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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