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Literature summary extracted from
- Hydroxymethylglutaryl coenzyme A reductase purification and properties of the enzyme from Fusarium oxysporum (1978), Biochim. Biophys. Acta, 523, 283-296.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.34 | 0.021 | - |
3-hydroxy-3-methylglutaryl-CoA | - |
Fusarium oxysporum |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.34 | cytosol | - |
Fusarium oxysporum | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 11000 | - |
- |
Fusarium oxysporum |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | Fusarium oxysporum | - |
(R)-mevalonate + CoA + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.34 | Fusarium oxysporum | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.34 | - |
Fusarium oxysporum |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 0.145 | - |
- |
Fusarium oxysporum |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.1.1.34 | 0°C, 24 h, 25% loss of activity | Fusarium oxysporum |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Fusarium oxysporum | (R)-mevalonate + CoA + NADP+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.34 | monomer | 1 * 11000, SDS-PAGE | Fusarium oxysporum |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 37 | - |
- |
Fusarium oxysporum |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 15 | 50 | - |
Fusarium oxysporum |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 7.4 | - |
- |
Fusarium oxysporum |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 6 | 9 | - |
Fusarium oxysporum |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.34 | NADH | - |
Fusarium oxysporum | |
| 1.1.1.34 | NADPH | - |
Fusarium oxysporum | |
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