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Literature summary extracted from

  • Ingebritsen, T.S.; Parker, R.A.; Gibson, D.M.
    Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system (1981), J. Biol. Chem., 256, 1138-1144.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.3 additional information cAMP-independent enzyme Rattus norvegicus
2.7.11.31 additional information no activation by cGMP Rattus norvegicus
2.7.11.31 additional information no activation by cAMP Rattus norvegicus
2.7.11.31 additional information no activation by cIMP, cCMP Rattus norvegicus
2.7.11.31 Reductase kinase kinase activation, i.e. EC 2.7.1.110, in the presence of MgATP2- Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.3 additional information no inhibition by inhibitor of cAMP-dependent protein kinase Rattus norvegicus
2.7.11.31 protein phosphatase C
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 microsome
-
 Rattus norvegicus
-
-
2.7.11.3 cytosol predominant Rattus norvegicus 5829
-
2.7.11.3 additional information subcellular distribution Rattus norvegicus
-
-
2.7.11.31 cytosol predominant Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.3 Mg2+ requirement, actual substrate: MgATP Rattus norvegicus
2.7.11.31 Mg2+ requirement, actual substrate: MgATP2- Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Rattus norvegicus
-
 (R)-mevalonate + CoA + NADP+
-
 ?
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Rattus norvegicus Wistar
-
 (R)-mevalonate + CoA + NADP+
-
 ?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus Wistar phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Rattus norvegicus
-
-
-
2.7.11.3 Rattus norvegicus
-
 Wistar
-
2.7.11.3 Rattus norvegicus Wistar
-
 Wistar
-
2.7.11.31 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.1.1.34 phosphoprotein activity is regulated by phosphorylation and dephosphorylation Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.34
-
 Rattus norvegicus
2.7.11.3 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 liver
-
 Rattus norvegicus
-
2.7.11.3 liver
-
 Rattus norvegicus
-
2.7.11.31 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Rattus norvegicus (R)-mevalonate + CoA + NADP+
-
 ?
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Rattus norvegicus Wistar (R)-mevalonate + CoA + NADP+
-
 ?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 Rattus norvegicus Wistar ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Rattus norvegicus Wistar ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.31 ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?
2.7.11.31 ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus Wistar ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.31 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.3 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Rattus norvegicus