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Literature summary extracted from

  • Sipat, A.P.
    Hydroxymethylglutaryl CoA reductase (NADPH) in the latex of Hevea brasiliensis (1982), Phytochemistry, 21, 2613-2618.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.34 dithiothreitol 2 mM Hevea brasiliensis
1.1.1.34 thiol
-
 Hevea brasiliensis

General Stability

EC Number General Stability Organism
1.1.1.34 presence of reduced thiol compounds is important for enzyme stability Rattus norvegicus
1.1.1.34 presence of reduced thiol compounds is important for enzyme stability Pisum sativum
1.1.1.34 presence of reduced thiol compounds is important for enzyme stability Hevea brasiliensis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 CoASH
-
 Pisum sativum
1.1.1.34 CoASH
-
 Rattus norvegicus
1.1.1.34 Hydroxymethylglutarate 2 mM, slightly inhibitory Hevea brasiliensis
1.1.1.34 Hydroxymethylglutarate
-
 Pisum sativum
1.1.1.34 MgATP2- 4 mM Hevea brasiliensis
1.1.1.34 MgATP2-
-
 Rattus norvegicus
1.1.1.34 p-chloromercuribenzoate 1 mM, complete inhibition Hevea brasiliensis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.34 0.056
-
 (R,S)-3-hydroxy-3-methylglutaryl-CoA
-
 Hevea brasiliensis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
1.1.1.34 endoplasmic reticulum
-
 Pisum sativum 5783
-
1.1.1.34 membrane lutoid Hevea brasiliensis 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Rattus norvegicus
-
 (R)-mevalonate + CoA + NADP+
-
 ?
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Pisum sativum
-
 (R)-mevalonate + CoA + NADP+
-
 ?
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Hevea brasiliensis
-
 (R)-mevalonate + CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Hevea brasiliensis
-
-
-
1.1.1.34 Pisum sativum
-
-
-
1.1.1.34 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 latex
-
 Hevea brasiliensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Rattus norvegicus (R)-mevalonate + CoA + NADP+
-
 ?
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Pisum sativum (R)-mevalonate + CoA + NADP+
-
 ?
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Hevea brasiliensis (R)-mevalonate + CoA + NADP+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.34 30
-
 assay at Hevea brasiliensis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.34 6.5 7.5
-
 Rattus norvegicus
1.1.1.34 6.6 6.9
-
 Hevea brasiliensis
1.1.1.34 6.8
-
-
 Pisum sativum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADH
-
 Hevea brasiliensis
1.1.1.34 NADPH
-
 Rattus norvegicus
1.1.1.34 NADPH
-
 Pisum sativum
1.1.1.34 NADPH
-
 Hevea brasiliensis