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Literature summary extracted from

  • Feingold, K.R.; Moser, A.H.
    The effect of substrates and competitive inhibitors on the phosphatase dependent activation of hepatic hydroxymethylglutaryl CoA reductase (1986), Arch. Biochem. Biophys., 249, 46-51.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 adenosine-2'-monophospho-5'-diphosphoribose competitive inhibitor for NADPH binding site Rattus norvegicus
1.1.1.34 Compactin competitive inhibitor for HMG-CoA binding site Rattus norvegicus
1.1.1.34 lovastatin competitive inhibitor for HMG-CoA binding site Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Rattus norvegicus
-
 (R)-mevalonate + CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.1.1.34 phosphoprotein activity is regulated by phosphorylation and dephosphorylation Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Rattus norvegicus (R)-mevalonate + CoA + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Rattus norvegicus