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Literature summary extracted from

  • Hupperich, M.; Thomer, A.; Kratz, K.; Eggerer, H.
    Substrate and inhibitor specificity of 3-hydroxy-3-methylglutaryl-CoA reductase determined with substrate-analogue CoA-thioesters and CoA-thioethers (1991), Biol. Chem. Hoppe-Seyler, 372, 857-863.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 (S)-4-carboxy-3-hydroxy-3-methylbutyryl-CoA competitive inhibitor Homo sapiens
1.1.1.34 (S)-4-carboxy-3-hydroxybutyryl-CoA competitive inhibitor Homo sapiens
1.1.1.34 3,3-dimethylglutaryl-CoA competitive inhibitor Homo sapiens
1.1.1.34 3-hydroxyglutaryl-CoA competitive inhibitor Homo sapiens
1.1.1.34 3-methylglutaryl-CoA competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Homo sapiens
-
 (R)-mevalonate + CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Homo sapiens (R)-mevalonate + CoA + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Homo sapiens