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Literature summary extracted from

  • Concepcion, J.L.; Gonzalez-Pakanowska, D.; Urbina, J.A.
    3-Hydroxy-3-methylglutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: Subcellular localization and kinetic properties (1998), Arch. Biochem. Biophys., 352, 114-120.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 lovastatin competitive inhibitor for HMG-CoA binding site and noncompetitive inhibitor for NADPH binding site Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.34 0.028
-
 3-hydroxy-3-methylglutaryl-CoA
-
 Trypanosoma cruzi
1.1.1.34 0.037
-
 NADPH
-
 Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 cytosol
-
 Trypanosoma cruzi 5829
-
1.1.1.34 glycosome
-
 Trypanosoma cruzi 20015
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Trypanosoma cruzi
-
 (R)-mevalonate + CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Trypanosoma cruzi
-
 Schizotrypanum
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.34
-
 Trypanosoma cruzi

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.34 0.0164
-
-
 Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Trypanosoma cruzi (R)-mevalonate + CoA + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Trypanosoma cruzi