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Literature summary extracted from

  • McReynolds, M.S.; Barrie Kitto, G.
    Purification and properties of Drosophila malate dehydrogenase (1970), Biochim. Biophys. Acta, 198, 165-175.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.37 oxaloacetate
-
 Drosophila virilis
1.1.1.37 oxaloacetate
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.37 0.04
-
 oxaloacetate cytoplasmic enzyme Drosophila virilis
1.1.1.37 0.047
-
 oxaloacetate mitochondrial enzyme Drosophila virilis
1.1.1.37 8
-
 L-malate cytoplasmic isoenzyme Drosophila virilis
1.1.1.37 20
-
 L-malate mitochondrial isoenzyme Drosophila virilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.37 cytoplasm
-
 Sus scrofa 5737
-
1.1.1.37 cytoplasm
-
 Bos taurus 5737
-
1.1.1.37 cytoplasm
-
 Gallus sp. 5737
-
1.1.1.37 cytoplasm
-
 Drosophila virilis 5737
-
1.1.1.37 cytoplasm
-
 Equus sp. 5737
-
1.1.1.37 cytoplasm
-
 Thunnus albacares 5737
-
1.1.1.37 mitochondrion
-
 Drosophila melanogaster 5739
-
1.1.1.37 mitochondrion
-
 Sus scrofa 5739
-
1.1.1.37 mitochondrion
-
 Bos taurus 5739
-
1.1.1.37 mitochondrion
-
 Gallus sp. 5739
-
1.1.1.37 mitochondrion
-
 Drosophila virilis 5739
-
1.1.1.37 mitochondrion
-
 Equus sp. 5739
-
1.1.1.37 mitochondrion
-
 Thunnus albacares 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.37 67000
-
-
 Sus scrofa
1.1.1.37 67000
-
-
 Gallus sp.
1.1.1.37 67000
-
-
 Thunnus albacares
1.1.1.37 68000
-
-
 Sus scrofa
1.1.1.37 68000
-
 both isoenzymes, gel filtration Drosophila melanogaster
1.1.1.37 68000
-
 both isoenzymes, gel filtration Drosophila virilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.37 malate + NAD+ Drosophila melanogaster
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Sus scrofa
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Bos taurus
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Locusta migratoria
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Gallus sp.
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Drosophila virilis
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Equus sp.
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Thunnus albacares
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Drosophila melanogaster Oregon K
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Drosophila virilis Texmelucan
-
 oxaloacetate + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.37 Bos taurus
-
 ox
-
1.1.1.37 Drosophila melanogaster
-
 Oregon K
-
1.1.1.37 Drosophila melanogaster Oregon K
-
 Oregon K
-
1.1.1.37 Drosophila virilis
-
 Texmelucan
-
1.1.1.37 Drosophila virilis Texmelucan
-
 Texmelucan
-
1.1.1.37 Equus sp.
-
 horse
-
1.1.1.37 Gallus sp.
-
 chicken
-
1.1.1.37 Locusta migratoria
-
-
-
1.1.1.37 Sus scrofa
-
 pig
-
1.1.1.37 Thunnus albacares
-
 tuna
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.37
-
 Drosophila melanogaster
1.1.1.37
-
 Locusta migratoria
1.1.1.37
-
 Drosophila virilis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.37 heart
-
 Sus scrofa
-
1.1.1.37 heart
-
 Bos taurus
-
1.1.1.37 heart
-
 Gallus sp.
-
1.1.1.37 heart
-
 Equus sp.
-
1.1.1.37 heart
-
 Thunnus albacares
-
1.1.1.37 kidney
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.37 1670
-
-
 Drosophila virilis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.37 (S)-malate + NAD+
-
 Drosophila melanogaster oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Sus scrofa oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Bos taurus oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Locusta migratoria oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Gallus sp. oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Drosophila virilis oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Equus sp. oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Thunnus albacares oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Drosophila melanogaster Oregon K oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Drosophila virilis Texmelucan oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Drosophila melanogaster oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Sus scrofa oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Bos taurus oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Locusta migratoria oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Gallus sp. oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Drosophila virilis oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Equus sp. oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Thunnus albacares oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Drosophila melanogaster Oregon K oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Drosophila virilis Texmelucan oxaloacetate + NADH + H+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Drosophila melanogaster L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Sus scrofa L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Bos taurus L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Locusta migratoria L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Gallus sp. L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Drosophila virilis L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Equus sp. L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Thunnus albacares L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Drosophila melanogaster Oregon K L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Drosophila virilis Texmelucan L-malate + NAD+
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.37 8.5
-
 oxaloacetate reduction Drosophila melanogaster
1.1.1.37 8.5
-
 oxaloacetate reduction Drosophila virilis
1.1.1.37 9
-
 malate oxidation, cytoplasmic isoenzymes Drosophila melanogaster
1.1.1.37 9
-
 malate oxidation, cytoplasmic isoenzymes Drosophila virilis
1.1.1.37 9.5
-
 mitochondrial isoenzyme Drosophila melanogaster
1.1.1.37 9.5
-
 mitochondrial isoenzyme Drosophila virilis