Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cohen, P.F.; Colman, R.F.
    Role of manganous ion in the kinetics of pig-heart NAD-specific isocitrate dehydrogenase (1974), Eur. J. Biochem., 47, 35-45.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.41 Co2+ less effective than Mg2+ or Mn2+ Sus scrofa
1.1.1.41 Mg2+ required, active substrate is Mg-DL-isocitrate chelate Sus scrofa
1.1.1.41 Mn2+ requires divalent cations Sus scrofa
1.1.1.41 Zn2+ less effective than Mn2+ or Mg2+ Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.41 isocitrate + NAD+ Sus scrofa
-
 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.41 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.41
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.41 heart
-
 Sus scrofa
-

Storage Stability

EC Number Storage Stability Organism
1.1.1.41 -90°C, no loss of activity after 6 weeks Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.41 isocitrate + NAD+
-
 Sus scrofa 2-oxoglutarate + CO2 + NADH + H+
-
 ?

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.41 6 8
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.41 NAD+
-
 Sus scrofa