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Literature summary extracted from
- Purification and properties of NADP+:isocitrate dehydrogenase from lactating bovine mammary gland (1980), Arch. Biochem. Biophys., 204, 551-559.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.1.1.42 | stabilization by dithiothreitol | Bos taurus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.42 | glyoxylate | plus oxaloacetate | Bos taurus |  |
| 1.1.1.42 | p-chloromercuribenzoate | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.42 | 0.011 | - |
NADP+ | - |
Bos taurus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.42 | Cd2+ | absolute requirement for divalent cations | Bos taurus | |
| 1.1.1.42 | Co2+ | absolute requirement for divalent cations | Bos taurus | |
| 1.1.1.42 | Mg2+ | absolute requirement for divalent cations | Bos taurus | |
| 1.1.1.42 | Mn2+ | absolute requirement for divalent cations | Bos taurus | |
| 1.1.1.42 | Zn2+ | absolute requirement for divalent cations | Bos taurus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.42 | 55000 | - |
PAGE | Bos taurus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.42 | isocitrate + NADP+ | Bos taurus | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.42 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.42 | - |
Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.42 | mammary gland | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.42 | isocitrate + NADP+ | - |
Bos taurus | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.42 | 7.2 | 8.2 | - |
Bos taurus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.42 | 6 | 9.5 | - |
Bos taurus |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.42 | 6 | - |
- |
Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.42 | NADP+ | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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