Literature summary extracted from

Chen, R.; Greer, A.F.; Dean, A.M.
Structural constrains in protein engineering. The coenzyme specificity of Escherichia coli isocitrate dehydrogenase (1997), Eur. J. Biochem., 250, 578-582.

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.1.1.42	C201M	higher affinity for NAD+ than for NADP+	Escherichia coli
1.1.1.42	C201N	higher affinity for NAD+ than for NADP+	Escherichia coli
1.1.1.42	C201V	higher affinity for NAD+ than for NADP+	Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.42	isocitrate + NADP+	Escherichia coli	-	2-oxoglutarate + NADPH + H+ + CO2	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.42	Escherichia coli	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.42	isocitrate + NADP+	-	Escherichia coli	2-oxoglutarate + NADPH + H+ + CO2	-	?

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Release 2023.1 (January 2023)