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Literature summary extracted from
- Drosophila beta-L-hydroxy acid dehydrogenase (1970), J. Biol. Chem., 246, 5345-5350.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.45 | additional information | - |
additional information | kinetic studies | Drosophila melanogaster | |
| 1.1.1.45 | 0.25 | - |
L-gulonate | cofactor NAD+ | Drosophila melanogaster |  |
| 1.1.1.45 | 22.8 | - |
L-3-hydroxybutanoate | cofactor NAD+ | Drosophila melanogaster | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.45 | 63000 | - |
sucrose density gradient centrifugation | Drosophila melanogaster |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.45 | L-gulonic acid + NAD+ | Drosophila melanogaster | - |
3-dehydro-L-gulonic acid + NADH + H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.45 | Drosophila melanogaster | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.45 | - |
Drosophila melanogaster |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.45 | 12 | - |
- |
Drosophila melanogaster |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.45 | L-3-hydroxybutanoate + NADH | - |
Drosophila melanogaster | acetoacetate + NAD+ | - |
r | |
| 1.1.1.45 | L-gulonic acid + NAD+ | - |
Drosophila melanogaster | 3-dehydro-L-gulonic acid + NADH + H+ | - |
? | |
| 1.1.1.45 | L-gulonic acid + NAD+ | - |
Drosophila melanogaster | 3-dehydro-L-gulonic acid + NADH + H+ | - |
r | |
| 1.1.1.45 | additional information | no substrates are: DL-2-hydroxybutanoate, DL-4-hydroxybutanoate, 2-butanol, DL-3-hydroxypropionate, L-threonine | Drosophila melanogaster | ? | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.45 | 8.2 | - |
- |
Drosophila melanogaster |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.45 | 7 | 10 | oxidation of 3-hydroxybutanoate | Drosophila melanogaster |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.45 | NAD+ | - |
Drosophila melanogaster | |
| 1.1.1.45 | NADH | - |
Drosophila melanogaster | |
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Release 2023.1 (January 2023)
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