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Literature summary extracted from

  • Guenthner, T.M.; Cai, D.; Wallin, R.
    Co-purification of microsomal epoxide hydrolase with the warfarin-sensitive vitamin K cycle (1998), Biochem. Pharmacol., 55, 169-175.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.4 warfarin 0.01 mM, 85% inhibition, 0.025 mM, 92% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.4.4 0.065
-
 styrene 1',2'-oxide
-
 Rattus norvegicus
1.17.4.4 0.805
-
 allylbenzene 2',3'-oxide
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.4 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.4.4
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.4 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.4.4 0.0167
-
-
 Rattus norvegicus
1.17.4.4 0.108
-
 substrate styrene 1',2'-oxide Rattus norvegicus
1.17.4.4 0.718
-
 substrate allylbenzene 2',3'-oxide Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.4 allylbenzene 2',3'-oxide + 1,4-dithiothreitol
-
 Rattus norvegicus allylbenzene + oxidized dithiothreitol
-
 ?
1.17.4.4 styrene 1',2'-oxide + 1,4-dithiothreitol
-
 Rattus norvegicus styrene + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?