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Literature summary extracted from

  • Jakoby, W.B.; Scott, E.M.
    Aldehyde oxidation III. Succinic semialdehyde dehydrogenase (1959), J. Biol. Chem., 234, 937-940.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.16 2-mercaptoethanol convenient source of exogenous mercaptan, 5 mM Pseudomonas fluorescens
1.2.1.16 cysteine
-
 Pseudomonas fluorescens
1.2.1.16 glutathione
-
 Pseudomonas fluorescens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.16 glyoxylate
-
 Pseudomonas fluorescens
1.2.1.16 malonic semialdehyde
-
 Pseudomonas fluorescens
1.2.1.16 potassium arsenite
-
 Pseudomonas fluorescens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.16 Pseudomonas fluorescens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.16
-
 Pseudomonas fluorescens

Storage Stability

EC Number Storage Stability Organism
1.2.1.16 2°C, pH 7.0, 10% loss of activity per week Pseudomonas fluorescens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.16 succinate semialdehyde + NADP+ + H2O
-
 Pseudomonas fluorescens succinate + NADPH + H+
-
 ir

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.16 8.5
-
-
 Pseudomonas fluorescens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.16 7 9.3 at pH 7.0 and 9.3: about 30% of activity maximum Pseudomonas fluorescens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.2.1.16 6.5 7.1 highest stability Pseudomonas fluorescens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.16 NAD+ NADP+ is about 8.2 times as active as NAD+ Pseudomonas fluorescens
1.2.1.16 NADP+ NADP+ is 8.2 times as active as NAD+ Pseudomonas fluorescens