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Literature summary extracted from
- alpha-Ketoglutaric semialdehyde dehydrogenase of Pseudomonas. Properties of the purified enzyme induced by hydroxyproline and of the glucarate-induced and constitutive enzymes (1967), J. Biol. Chem., 242, 1802-1814.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.26 | 4-Hydroxy-alpha-ketoglutaric semialdehyde | - |
Pseudomonas sp. |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.26 | 0.016 | - |
Glutaric semialdehyde | - |
Pseudomonas sp. | |
| 1.2.1.26 | 0.05 | 0.1 | 2,5-dioxopentanoate | - |
Pseudomonas sp. | |
| 1.2.1.26 | 0.1 | - |
NADP+ | - |
Pseudomonas sp. | |
| 1.2.1.26 | 0.5569 | - |
NAD+ | - |
Pseudomonas sp. | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.26 | 115000 | - |
sucrose density gradient centrifugation | Pseudomonas sp. |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.26 | 2,5-dioxopentanoate + NAD(P)+ + H2O | Pseudomonas sp. | - |
2-oxoglutarate + NAD(P)H | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.1.26 | Pseudomonas sp. | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.2.1.26 | - |
Pseudomonas sp. |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.26 | 53 | - |
- |
Pseudomonas sp. |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.26 | 2,5-dioxopentanoate + NAD(P)+ + H2O | - |
Pseudomonas sp. | 2-oxoglutarate + NAD(P)H | - |
? | |
| 1.2.1.26 | 2,5-dioxopentanoate + NAD+ + H2O | - |
Pseudomonas sp. | 2-oxoglutarate + NADH + H+ | - |
r | |
| 1.2.1.26 | glutaric semialdehyde + NADP+ + H2O | - |
Pseudomonas sp. | glutarate + NADPH | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.26 | 8.5 | - |
2,5-dioxopentanoate + NADP+ | Pseudomonas sp. |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.26 | 5.2 | - |
not active below, 2,5-dioxopentanoate + NADP+ | Pseudomonas sp. |
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Release 2023.1 (January 2023)
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