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Literature summary extracted from

  • Simard, J.; Melner, M.H.; Breton, N.; Low, K.G.; Zhao, H.F.; Periman, L.M.; Labrie, F.
    Characterization of macaque 3beta-hydroxy-5-ene steroid dehydrogenase/DELTA5-DELTA4-isomerase: structure and expression in steroidogenic and peripheral tissues in primate (1991), Mol. Cell. Endocrinol., 75, 101-110.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.3.1
-
 Macaca mulatta

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.3.1 integral to membrane
-
 Macaca mulatta
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.145 41874
-
 x * 41874, calculated from cDNA Macaca mulatta
5.3.3.1 41874
-
 x * 41874, calculation from nucleotide sequence Macaca mulatta

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 pregnenolone + NAD(P)+ Macaca mulatta
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?
5.3.3.1 additional information Macaca mulatta the conversion of 3beta-hydroxy-5-ene steroids by the enzyme complex 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase is an obligatory step in the biosynthesis of all classes of hormonal steroids in classical steroidogenic as well as in peripheral tissues ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Macaca mulatta
-
-
-
5.3.3.1 Macaca mulatta
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.3.1 adrenal gland
-
 Macaca mulatta
-
5.3.3.1 epididymis
-
 Macaca mulatta
-
5.3.3.1 kidney
-
 Macaca mulatta
-
5.3.3.1 liver
-
 Macaca mulatta
-
5.3.3.1 ovary
-
 Macaca mulatta
-
5.3.3.1 testis
-
 Macaca mulatta
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 pregnenolone + NAD(P)+
-
 Macaca mulatta pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?
5.3.3.1 additional information the conversion of 3beta-hydroxy-5-ene steroids by the enzyme complex 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase is an obligatory step in the biosynthesis of all classes of hormonal steroids in classical steroidogenic as well as in peripheral tissues Macaca mulatta ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.145 ? x * 41874, calculated from cDNA Macaca mulatta
5.3.3.1 ? x * 41874, calculation from nucleotide sequence Macaca mulatta

Synonyms

EC Number Synonyms Comment Organism
5.3.3.1 More 3beta-HSD Macaca mulatta
5.3.3.1 More enzyme complex 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase Macaca mulatta
5.3.3.1 More beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase Macaca mulatta

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
 Macaca mulatta