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Literature summary extracted from

  • Banthorpe, D.V.; Doonan, S.; Gutowski, J.A.
    Isopentenyl pyrophosphate isomerase from pig liver (1977), Arch. Biochem. Biophys., 184, 381-390.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.3.3.2 2-mercaptoethanol activates Sus scrofa
5.3.3.2 dithiothreitol activates Sus scrofa
5.3.3.2 glutathione activates Sus scrofa
5.3.3.2 L-Cysteine hydrochloride activates Sus scrofa
5.3.3.2 mevalonic acid activates Sus scrofa
5.3.3.2 Mevalonic acid lactone weakly activates Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.3.2 (+/-)-cis/trans-Chrysanthemyl diphosphate
-
 Sus scrofa
5.3.3.2 (+/-)-cis/trans-Chrysanthemyl monophosphate
-
 Sus scrofa
5.3.3.2 2,2-Diphenyl-1-(beta-dimethylaminoethoxy)pentane hydrochloride
-
 Sus scrofa
5.3.3.2 ATP partial Sus scrofa
5.3.3.2 beta-Diethylaminoethyldiphenylpropylacetate hydrochloride i.e. SKF-525A Sus scrofa
5.3.3.2 geranyl diphosphate
-
 Sus scrofa
5.3.3.2 geranyl monophosphate
-
 Sus scrofa
5.3.3.2 iodoacetamide
-
 Sus scrofa
5.3.3.2 iodoacetic acid
-
 Sus scrofa
5.3.3.2 KH2PO4
-
 Sus scrofa
5.3.3.2 linaloyl diphosphate
-
 Sus scrofa
5.3.3.2 linaloyl monophosphate
-
 Sus scrofa
5.3.3.2 NEM
-
 Sus scrofa
5.3.3.2 neryl diphosphate
-
 Sus scrofa
5.3.3.2 Neryl monophosphate
-
 Sus scrofa
5.3.3.2 p-hydroxymercuribenzoate
-
 Sus scrofa
5.3.3.2 Sodium acetate
-
 Sus scrofa
5.3.3.2 Terpene diphosphate esters
-
 Sus scrofa
5.3.3.2 Terpene monophosphate esters
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.3.2 0.0027
-
 isopentenyl diphosphate
-
 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.3.3.2 Mg2+ restores activity after EDTA treatment Sus scrofa
5.3.3.2 Mg2+ maximal activation at 5 mM Sus scrofa
5.3.3.2 Mn2+ restores activity after EDTA treatment Sus scrofa
5.3.3.2 Mn2+ maximal activation at 2 mM, activity maximum obtained with Mn2+ is about 3times that with Mg2+ Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.3.2 82500
-
 gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
5.3.3.2 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.3.2
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.3.2 liver
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.3.3.2 5.92
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.3.2 isopentenyl diphosphate
-
 Sus scrofa dimethylallyl diphosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.3.3.2 6.3
-
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
5.3.3.2 5.5 7.5 pH 5.5: about 35% of maximal activity, pH 7.5: about 30% of maximal activity Sus scrofa