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Literature summary extracted from
- The roles of protein C and thrombomodulin in the regulation of blood coagulation (1989), J. Biol. Chem., 264, 4743-4746.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.69 | - |
Homo sapiens |
| 3.4.21.69 | - |
Bos taurus |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.69 | Ca2+ | contains gamma-carboxyglutamic acid residues required for Ca2+-dependent membrane binding | Homo sapiens |  |
| 3.4.21.69 | Ca2+ | contains gamma-carboxyglutamic acid residues required for Ca2+-dependent membrane binding | Bos taurus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.69 | additional information | Homo sapiens | role of protein C in the regulation of blood coagulation | ? | - |
? | |
| 3.4.21.69 | additional information | Bos taurus | role of protein C in the regulation of blood coagulation | ? | - |
? | |
| 3.4.21.69 | additional information | Homo sapiens | activated protein C complexes with protein S on the surface of either platelets or the endothelium, these complexes catalyze the proteolytic inactivation of factors Va and VIIIa | ? | - |
? | |
| 3.4.21.69 | additional information | Bos taurus | activated protein C complexes with protein S on the surface of either platelets or the endothelium, these complexes catalyze the proteolytic inactivation of factors Va and VIIIa | ? | - |
? | |
| 3.4.21.69 | additional information | Homo sapiens | the enzyme is one of the gamma-carboxyglutamic acid-containing coagulation factors. It is formed by protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin or by serine endopeptidases present in several snake venoms | ? | - |
? | |
| 3.4.21.69 | additional information | Bos taurus | the enzyme is one of the gamma-carboxyglutamic acid-containing coagulation factors. It is formed by protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin or by serine endopeptidases present in several snake venoms | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.69 | Bos taurus | - |
- |
- |
| 3.4.21.69 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.69 | plasma | - |
Homo sapiens | - |
| 3.4.21.69 | plasma | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.69 | Factor Va + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.69 | Factor Va + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.69 | Factor VIIIa + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.69 | Factor VIIIa + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.69 | additional information | role of protein C in the regulation of blood coagulation | Homo sapiens | ? | - |
? | |
| 3.4.21.69 | additional information | role of protein C in the regulation of blood coagulation | Bos taurus | ? | - |
? | |
| 3.4.21.69 | additional information | activated protein C complexes with protein S on the surface of either platelets or the endothelium, these complexes catalyze the proteolytic inactivation of factors Va and VIIIa | Homo sapiens | ? | - |
? | |
| 3.4.21.69 | additional information | activated protein C complexes with protein S on the surface of either platelets or the endothelium, these complexes catalyze the proteolytic inactivation of factors Va and VIIIa | Bos taurus | ? | - |
? | |
| 3.4.21.69 | additional information | the enzyme is one of the gamma-carboxyglutamic acid-containing coagulation factors. It is formed by protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin or by serine endopeptidases present in several snake venoms | Homo sapiens | ? | - |
? | |
| 3.4.21.69 | additional information | the enzyme is one of the gamma-carboxyglutamic acid-containing coagulation factors. It is formed by protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin or by serine endopeptidases present in several snake venoms | Bos taurus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.69 | More | in humans 40% of the protein S circulates free and 60% in a reversible complex with C4b binding protein | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.69 | vitamin K | enzyme is dependent on | Homo sapiens | |
| 3.4.21.69 | vitamin K | enzyme is dependent on | Bos taurus | |
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