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Literature summary extracted from

  • Kisiel, W.; Davie, E.W.
    Protein C (1981), Methods Enzymol., 80, 320-332.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.69 Benzamidine hydrochloride
-
Bos taurus
3.4.21.69 Benzamidine hydrochloride
-
Homo sapiens
3.4.21.69 diisopropyl fluorophosphate
-
Bos taurus
3.4.21.69 diisopropyl fluorophosphate
-
Homo sapiens
3.4.21.69 phenylmethylsulfonyl fluoride
-
Bos taurus
3.4.21.69 phenylmethylsulfonyl fluoride
-
Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.69 21000
-
1 * 41000 + 1 * 21000, bovine protein C, SDS-PAGE of reduced protein, heavy and light chain are connected by a disulfide bond, cleavage of Arg12-Leu13 in the heavy chain releases a small activation peptide, MW 1400 and protein Ca Bos taurus
3.4.21.69 41000
-
1 * 41000 + 1 * 21000, bovine protein C, SDS-PAGE of reduced protein, heavy and light chain are connected by a disulfide bond, cleavage of Arg12-Leu13 in the heavy chain releases a small activation peptide, MW 1400 and protein Ca Bos taurus
3.4.21.69 54300
-
bovine, protein C, amino acid and carbohydrate composition data, conversion to protein Ca by hydrolysis of a specific peptide bond in the amino-terminal region of the heavy chain between Arg14 and Ile15, giving rise to protein Ca, MW 52650 and an activation peptide, MW 1650 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.69 Bos taurus
-
-
-
3.4.21.69 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.69 glycoprotein bovine protein C contains 14% carbohydrate, approximately 15 residues of hexose, 12 residues of hexosamine and 9 residues of sialic acid distributed in 3 carbohydrate chains, human protein C contains 23% carbohydrate, approximately 14 residues of galactose, 21 residues of mannose, 23 residues of glucosamine and 12 residues of sialic acid Homo sapiens
3.4.21.69 glycoprotein bovine protein C contains 14% carbohydrate, approximately 15 residues of hexose, 12 residues of hexosamine and 9 residues of sialic acid distributed in 3 carbohydrate chains, human protein C contains 23% carbohydrate, approximately 14 residues of galactose, 21 residues of mannose, 23 residues of glucosamine and 12 residues of sialic acid Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.69
-
Homo sapiens
3.4.21.69
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.69 plasma
-
Homo sapiens
-
3.4.21.69 plasma
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.69 Factor Va + H2O
-
Homo sapiens ?
-
?
3.4.21.69 Factor Va + H2O
-
Bos taurus ?
-
?
3.4.21.69 Factor VIIIa + H2O
-
Homo sapiens ?
-
?
3.4.21.69 Factor VIIIa + H2O
-
Bos taurus ?
-
?

Subunits

EC Number Subunits Comment Organism
3.4.21.69 dimer 1 * 41000 + 1 * 21000, bovine protein C, SDS-PAGE of reduced protein, heavy and light chain are connected by a disulfide bond, cleavage of Arg12-Leu13 in the heavy chain releases a small activation peptide, MW 1400 and protein Ca Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.21.69 vitamin K enzyme is dependent on Homo sapiens
3.4.21.69 vitamin K enzyme is dependent on Bos taurus