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Literature summary extracted from

  • Molloy, S.S.; Bresnahan, P.A.; Leppla, S.H.; Klimpel, K.R.; Thomas, G.
    Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen (1992), J. Biol. Chem., 267, 16396-16402.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.75 Ca2+ 5-10 mM inhibit; activation below Homo sapiens
3.4.21.75 diisopropyl fluorophosphate
-
Homo sapiens
3.4.21.75 dithiothreitol
-
Homo sapiens
3.4.21.75 EDTA
-
Homo sapiens
3.4.21.75 Hg2+
-
Homo sapiens
3.4.21.75 iodoacetamide
-
Homo sapiens
3.4.21.75 L-1-chloro-3-(4-tosylamido)-7-amino-2-heptanone
-
Homo sapiens
3.4.21.75 MnCl2
-
Homo sapiens
3.4.21.75 phenylmethanesulfonyl fluoride
-
Homo sapiens
3.4.21.75 Zn2+
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.75 Golgi membrane
-
Homo sapiens 139
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.75 Ca2+ required Homo sapiens
3.4.21.75 Ca2+ 5-10 mM inhibit Homo sapiens
3.4.21.75 Ca2+ half-maximal activity at: 0.2 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.75 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.75 additional information no processing of: human lactase-phlorizin hydrolase Homo sapiens ?
-
?
3.4.21.75 Protective antigen component of anthrax toxin + H2O cleavage at the sequence Arg-Lys-Lys-Arg Homo sapiens ?
-
?
3.4.21.75 tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
Homo sapiens tert-butoxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin
-
?

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.21.75 6 8.5 more than 50% of activity maximum at pH 6.0 and 8.5 Homo sapiens