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Literature summary extracted from
- A new thiol proteinase from rat liver (1981), J. Biol. Chem., 256, 2567-2572.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.24 | 2-mercaptoethanol | activation, 4 mM | Rattus norvegicus |  |
| 3.4.22.24 | cysteine | activation, 4 mM | Rattus norvegicus | |
| 3.4.22.24 | DTT | activation, 2 mM | Rattus norvegicus | |
| 3.4.22.24 | EDTA | activation | Rattus norvegicus | |
| 3.4.22.24 | EDTA | 2 mM | Rattus norvegicus | |
| 3.4.22.24 | GSH | activation, 4 mM | Rattus norvegicus | |
| 3.4.22.24 | sulfhydryl compounds | activation | Rattus norvegicus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.24 | 4,4'-dipyridyl disulfide | - |
Rattus norvegicus | |
| 3.4.22.24 | antipain | - |
Rattus norvegicus | |
| 3.4.22.24 | iodoacetamide | - |
Rattus norvegicus | |
| 3.4.22.24 | iodoacetate | - |
Rattus norvegicus | |
| 3.4.22.24 | leupeptin | - |
Rattus norvegicus | |
| 3.4.22.24 | additional information | no inhibition by native ribonuclease A | Rattus norvegicus | |
| 3.4.22.24 | N-ethylmaleimide | - |
Rattus norvegicus | |
| 3.4.22.24 | Oxidized ribonuclease A | tyrosine aminotransferase as substrate | Rattus norvegicus | |
| 3.4.22.24 | PCMB | - |
Rattus norvegicus | |
| 3.4.22.24 | PMSF | - |
Rattus norvegicus | |
| 3.4.22.24 | tosyl-L-lysine chloromethyl ketone | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.22.24 | lysosome | - |
Rattus norvegicus | 5764 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.24 | Rattus norvegicus | - |
albino male Holtzman rats | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.24 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.24 | Acid-denatured hemoglobin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.22.24 | azocasein + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.22.24 | additional information | no hydrolysis of synthetic low MW substrates for exopeptidases, e.g. Gly-(L)-Phe-beta-naphthylamide, L-Ser-(L)-Tyr-beta-naphthylamide, L-Leu-beta-naphthylamide, L-Arg-beta-naphthylamide, L-leucinamide, hippuryl-L-arginine, hippuryl-L-phenylalanine, N-benzoyl-L-tyrosine ethyl ester | Rattus norvegicus | ? | - |
? | |
| 3.4.22.24 | additional information | little or no activity at 0øC with glucose 6-phosphate dehydrogenase, native ribonuclease A, native bovine serum albumin, cytochrome c or oxidized insulin B-chain | Rattus norvegicus | ? | - |
? | |
| 3.4.22.24 | Performic acid-oxidized ribonuclease A + H2O | even at 0øC | Rattus norvegicus | Hydrolyzed performic acid-oxidized ribonuclease A | several fragments | ? | |
| 3.4.22.24 | Tyrosine aminotransferase form I + H2O | thereby generating multiple forms of tyrosine aminotransferase | Rattus norvegicus | Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide | enzyme form III: dimer of MW 49000 | ? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.22.24 | - |
- |
assay at, tyrosine aminotransferase as substrate | Rattus norvegicus |
| 3.4.22.24 | 37 | - |
assay at, proteins as substrate | Rattus norvegicus |
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