Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hawkins, H.C.; Freedman, R.B.
    Thiol-protein disulphide oxidoreductases. Differences between protein disulphide-isomerase and glutathione-insulin transhydrogenase activities in ox liver (1976), Biochem. J., 159, 385-393.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.2 Bos taurus
-
 ox
-
5.3.4.1 Bos taurus
-
 ox
-
5.3.4.1 Bos taurus
-
 protein disulfide isomerase activity and glutathione-insulin transhydrogenase activity, EC 1.8.4.2, are catalyzed by a single enzyme protein
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.2 partially Bos taurus
5.3.4.1 ox Bos taurus
5.3.4.1 protein disulfide isomerase activity and glutathione-insulin transhydrogenase activity, EC 1.8.4.2, are catalyzed by a single enzyme protein Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.2 liver
-
 Bos taurus
-
5.3.4.1 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.4.2 additional information
-
-
 Bos taurus
1.8.4.2 0.01
-
 purified enzyme Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.2 GSH + insulin
-
 Bos taurus GSSG + reduced insulin chain A and B
-
 ?
1.8.4.2 GSH + protein disulfide
-
 Bos taurus GSSG + protein-dithiol
-
 ?
1.8.4.2 additional information glutathione-insulin transhydrogenase EC 1.8.4.2 and protein disulfide-isomerase EC 5.3.4.1 activities are not both catalyzed by a single enzyme species Bos taurus ?
-
 ?
5.3.4.1 Proteins native, reduced or with wrong disulfide bonds Bos taurus Proteins with correct disulfide bonds ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.2 More glutathione-insulin transhydrogenase EC 1.8.4.2 and protein disulfide-isomerase EC 5.3.4.1 activities are not both catalyzed by a single enzyme species Bos taurus