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Literature summary extracted from

  • Ibbetson, A.L.; Freedman, R.B.
    Thiol-protein disulphide oxidoreductases. Assay of microsomal membrane-bound glutathione-insulin transhydrogenase and comparison with protein disulphide-isomerase (1976), Biochem. J., 159, 377-384.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.4.1 deoxycholate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.4.2 0.029
-
 Insulin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.2 membrane
-
 Rattus norvegicus 16020
-
1.8.4.2 microsome
-
 Rattus norvegicus
-
-
5.3.4.1 endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.2 Rattus norvegicus
-
-
-
5.3.4.1 Rattus norvegicus
-
 glutathione-insulin transhydrogenase and protein disulfide-isomerase are both not catalyzed by a single enzyme species
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.2 liver
-
 Rattus norvegicus
-
5.3.4.1 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.4.2 additional information
-
 assay methods Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.2 GSH + protein disulfide
-
 Rattus norvegicus GSSG + protein-dithiol
-
 ?
1.8.4.2 additional information glutathione-insulin transhydrogenase EC 1.8.4.2 and protein disulfide-isomerase EC 5.3.4.1 activities are not both catalyzed by a single enzyme species Rattus norvegicus ?
-
 ?
5.3.4.1 Proteins native, reduced or with wrong disulfide bonds Rattus norvegicus Proteins with correct disulfide bonds ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.2 More glutathione-insulin transhydrogenase EC 1.8.4.2 and protein disulfide-isomerase EC 5.3.4.1 activities are not both catalyzed by a single enzyme species Rattus norvegicus