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Literature summary extracted from
- Partial purification and characterization of insulin protease and its intracellular inhibitor from rat liver (1984), Arch. Biochem. Biophys., 229, 604-611.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.56 | glutathione | stimulates | Rattus norvegicus |  |
| 3.4.24.56 | mercaptoethanol | stimulates | Rattus norvegicus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.56 | Ag+ | - |
Rattus norvegicus | |
| 3.4.24.56 | As3+ | - |
Rattus norvegicus | |
| 3.4.24.56 | Cu2+ | - |
Rattus norvegicus | |
| 3.4.24.56 | EDTA | - |
Rattus norvegicus | |
| 3.4.24.56 | EGTA | - |
Rattus norvegicus | |
| 3.4.24.56 | Inhibitor from rat liver homogenate | low-molecular-weight protein, order of greatest to least activity: pancreas, liver, kidney, testes, adrenal, lung, spleen, diaphragm, heart, muscle, brain, epididymal fad pad, skin | Rattus norvegicus | |
| 3.4.24.56 | NEM | - |
Rattus norvegicus | |
| 3.4.24.56 | p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
| 3.4.24.56 | Pb4+ | - |
Rattus norvegicus | |
| 3.4.24.56 | Sb3+ | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.56 | 0.000024 | - |
Insulin | - |
Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.56 | Ca2+ | activates (at 1 mM) | Rattus norvegicus | |
| 3.4.24.56 | Mg2+ | activates | Rattus norvegicus | |
| 3.4.24.56 | Mn2+ | reactivates after EDTA inhibition | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.56 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.56 | partial | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.56 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.56 | additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.56 | Insulin + H2O | - |
Rattus norvegicus | Hydrolyzed insulin | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.56 | 7.6 | - |
- |
Rattus norvegicus |
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