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Literature summary extracted from

  • He, X.Y.; Yang, S.Y.; Schulz, H.
    Inhibition of enoyl-CoA hydratase by long-chain L-3-hydroxyacyl-CoA and its possible effect on fatty acid oxidation (1992), Arch. Biochem. Biophys., 298, 527-531.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.17 (3S)-hydroxybutanoyl-CoA competitive Bos taurus
4.2.1.17 (3S)-hydroxyhexadecanoyl-CoA competitive, 50% inhibition at 0.00075 mM, 90% inhibition by 0.004 mM Bos taurus
4.2.1.17 3-ketohexadecanoyl-CoA 0.008 mM, 40% inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.17 0.009
-
 trans-2-hexadecenoyl-CoA pH 8, 25°C Bos taurus
4.2.1.17 0.022
-
 crotonyl-CoA pH 8, 25°C Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.17 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.17 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.17 crotonyl-CoA + H2O
-
 Bos taurus (3S)-3-hydroxybutanoyl-CoA
-
 ?
4.2.1.17 trans-2-decenoyl-CoA + H2O Vmax is 8fold lower than with crotonyl-CoA Bos taurus (3S)-hydroxydecanoyl-CoA
-
 ?
4.2.1.17 trans-2-hexadecenoyl-CoA + H2O Vmax is 82fold lower than with crotonyl-CoA Bos taurus (3S)-hydroxyhexadecanoyl-CoA
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.17 0.00035
-
 (3S)-hydroxyhexadecanoyl-CoA pH 8, 25°C Bos taurus
4.2.1.17 0.037
-
 (3S)-hydroxybutanoyl-CoA pH 8, 25°C Bos taurus