EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.2.5 | cloning and sequencing of the cDNA coding for p60, the chicken homologue of bifunctional formiminotransferase cyclodeaminase, a protein of 541 amino acids | Gallus gallus |
2.1.2.5 | expressed in HeLa cells | Gallus gallus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.1.2.5 | cytosol | - |
Gallus gallus | 5829 | - |
2.1.2.5 | Golgi membrane | localized on Golgi membranes as well as on some potentially Golgi complex-derived vesicular structures | Gallus gallus | 139 | - |
2.1.2.5 | Golgi vesicle | localized on Golgi membranes as well as on some potentially Golgi complex-derived vesicular structures | Gallus gallus | - |
- |
2.1.2.5 | microtubule | microtubule-binding protein | Gallus gallus | 5874 | - |
4.3.1.4 | cytoplasmic vesicle membrane | - |
Homo sapiens | 30659 | - |
4.3.1.4 | cytoplasmic vesicle membrane | - |
Gallus gallus | 30659 | - |
4.3.1.4 | Golgi apparatus | Golgi apparatus, formiminotransferase-cyclodeaminase enzyme complex | Homo sapiens | 5794 | - |
4.3.1.4 | Golgi apparatus | Golgi apparatus, formiminotransferase-cyclodeaminase enzyme complex | Rattus norvegicus | 5794 | - |
4.3.1.4 | Golgi apparatus | Golgi apparatus, formiminotransferase-cyclodeaminase enzyme complex | Gallus gallus | 5794 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.1.2.5 | 59100 | - |
x * 59100, calculated from the amino acid sequence | Gallus gallus |
4.3.1.4 | 59100 | - |
8 * 59100, calculation from sequence of amono acid, isoform of formiminotransferase-cyclodeaminase enzyme complex | Gallus gallus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.5 | N-formiminoglutamate + tetrahydrofolate | Gallus gallus | in addition to its enzymatic activity enzyme may have a second physiological function in mediating interaction of Golgi-derived membranes with microtubules | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
2.1.2.5 | N-formiminoglutamate + tetrahydrofolate | Gallus gallus | histidine degradation | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | Meleagris gallopavo | - |
? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | Homo sapiens | - |
? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | Rattus norvegicus | - |
? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | Canis lupus familiaris | - |
? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | Sus scrofa | - |
? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | Gallus gallus | - |
? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | Canis lupus familiaris Madin-Darby | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.5 | Gallus gallus | Q9YH58 | chicken, several isoforms of p60, bifunctional formiminotransferase cyclodeaminase | - |
2.1.2.5 | Meleagris gallopavo | - |
- |
- |
4.3.1.4 | Canis lupus familiaris | - |
Madin-Darby | - |
4.3.1.4 | Canis lupus familiaris Madin-Darby | - |
Madin-Darby | - |
4.3.1.4 | Gallus gallus | Q9YH58 | - |
- |
4.3.1.4 | Homo sapiens | - |
- |
- |
4.3.1.4 | Meleagris gallopavo | - |
- |
- |
4.3.1.4 | Rattus norvegicus | - |
- |
- |
4.3.1.4 | Sus scrofa | P53603 | - |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.1.2.5 | additional information | p60, bifunctional formiminotransferase cyclodeaminase, is post-translationally modified | Gallus gallus |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.2.5 | purification from liver | Meleagris gallopavo |
2.1.2.5 | purification from liver | Gallus gallus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.2.5 | hepatoma cell | DU249 chicken hepatoma cells, contain p60 but no measurable formiminotransferase activity, may be due to the low expression of p60 | Gallus gallus | - |
2.1.2.5 | liver | - |
Meleagris gallopavo | - |
2.1.2.5 | liver | - |
Gallus gallus | - |
4.3.1.4 | HeLa cell | isoform of the formiminotransferase cyclodeaminase enzyme complex | Homo sapiens | - |
4.3.1.4 | hepatoma cell | - |
Homo sapiens | - |
4.3.1.4 | hepatoma cell | isoform of the formiminotransferase cyclodeaminase enzyme complex | Gallus gallus | - |
4.3.1.4 | kidney | isoform of the formiminotransferase cyclodeaminase enzyme complex | Canis lupus familiaris | - |
4.3.1.4 | liver | - |
Homo sapiens | - |
4.3.1.4 | liver | - |
Rattus norvegicus | - |
4.3.1.4 | liver | - |
Sus scrofa | - |
4.3.1.4 | liver | isoforms of the formiminotransferase cyclodeaminase enzyme complex | Meleagris gallopavo | - |
4.3.1.4 | liver | isoforms of the formiminotransferase cyclodeaminase enzyme complex | Gallus gallus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.1.2.5 | 10.5 | - |
- |
Gallus gallus |
4.3.1.4 | additional information | - |
- |
Sus scrofa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.5 | additional information | p60: bifunctional formiminotransferase cyclodeaminase, can mediate interaction between trans-Golgi network derived vesicles and microtubule in vitro, p60 may bind to the polyglutamate on microtubules, globular hydrophilic protein | Meleagris gallopavo | ? | - |
? | |
2.1.2.5 | additional information | p60: bifunctional formiminotransferase cyclodeaminase, can mediate interaction between trans-Golgi network derived vesicles and microtubule in vitro, p60 may bind to the polyglutamate on microtubules, globular hydrophilic protein | Gallus gallus | ? | - |
? | |
2.1.2.5 | N-formiminoglutamate + tetrahydrofolate | in addition to its enzymatic activity enzyme may have a second physiological function in mediating interaction of Golgi-derived membranes with microtubules | Gallus gallus | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
2.1.2.5 | N-formiminoglutamate + tetrahydrofolate | histidine degradation | Gallus gallus | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
2.1.2.5 | tetrahydrofolate + N-formimino-L-glutamate | - |
Meleagris gallopavo | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
2.1.2.5 | tetrahydrofolate + N-formimino-L-glutamate | - |
Gallus gallus | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Meleagris gallopavo | 5,10-methenyltetrahydrofolate + NH3 | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Homo sapiens | 5,10-methenyltetrahydrofolate + NH3 | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Rattus norvegicus | 5,10-methenyltetrahydrofolate + NH3 | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Canis lupus familiaris | 5,10-methenyltetrahydrofolate + NH3 | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Sus scrofa | 5,10-methenyltetrahydrofolate + NH3 | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Gallus gallus | 5,10-methenyltetrahydrofolate + NH3 | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Canis lupus familiaris Madin-Darby | 5,10-methenyltetrahydrofolate + NH3 | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Meleagris gallopavo | ? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Homo sapiens | ? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Rattus norvegicus | ? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Canis lupus familiaris | ? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Sus scrofa | ? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Gallus gallus | ? | - |
? | |
4.3.1.4 | 5-formiminotetrahydrofolate | - |
Canis lupus familiaris Madin-Darby | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.2.5 | ? | x * 59100, calculated from the amino acid sequence | Gallus gallus |
4.3.1.4 | octamer | - |
Rattus norvegicus |
4.3.1.4 | octamer | - |
Sus scrofa |
4.3.1.4 | octamer | 8 * 59100, calculation from sequence of amono acid, isoform of formiminotransferase-cyclodeaminase enzyme complex | Gallus gallus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.1.2.5 | additional information | - |
pI: 6.13 | Gallus gallus |