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Literature summary extracted from

  • Saito, K.; Quearry, B.J.; Saito, M.; Nowak, T.S.Jr.; Markey S.P.; Heyes, M.P.
    Kynurenine 3-hydroxylase in brain: species activity differences and effect of gerbil cerebral ischemia (1993), Arch. Biochem. Biophys., 307, 104-109.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.9 anthranilic acid 22% inhibition at 2 mM and 11% inhibition at 0.2 mM Meriones unguiculatus
1.14.13.9 EDTA 68% inhibition at 2 mM Meriones unguiculatus
1.14.13.9 Kynurenic acid 13% inhibition at 2 mM and 5% inhibition at 0.2 mM Meriones unguiculatus
1.14.13.9 L-tryptophan 35% inhibition at 2 mM and 22% inhibition at 0.2 mM Meriones unguiculatus
1.14.13.9 xanthurenic acid 48% inhibition at 2 mM and 13% inhibition at 0.2 mM Meriones unguiculatus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.9 0.0164
-
 L-kynurenine
-
 Meriones unguiculatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.9 L-kynurenine + NADPH + O2 Rattus norvegicus
-
 ? + NADP+
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2 Meriones unguiculatus increased activity in injured brain regions following cerebral ischemia ? + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.9 Homo sapiens
-
-
-
1.14.13.9 Macaca mulatta
-
 male rhesus macaques
-
1.14.13.9 Meriones unguiculatus
-
 female mongolian gerbil
-
1.14.13.9 Mus musculus
-
 mouse, strain D57Bl/6J
-
1.14.13.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.9 brain
-
 Homo sapiens
-
1.14.13.9 brain
-
 Rattus norvegicus
-
1.14.13.9 brain
-
 Meriones unguiculatus
-
1.14.13.9 brain
-
 Macaca mulatta
-
1.14.13.9 intestine
-
 Meriones unguiculatus
-
1.14.13.9 kidney
-
 Rattus norvegicus
-
1.14.13.9 kidney
-
 Meriones unguiculatus
-
1.14.13.9 liver
-
 Rattus norvegicus
-
1.14.13.9 liver
-
 Meriones unguiculatus
-
1.14.13.9 lung
-
 Meriones unguiculatus
-
1.14.13.9 spleen
-
 Meriones unguiculatus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.13.9 additional information
-
-
 Mus musculus
1.14.13.9 additional information
-
-
 Homo sapiens
1.14.13.9 additional information
-
-
 Rattus norvegicus
1.14.13.9 additional information
-
-
 Macaca mulatta
1.14.13.9 additional information
-
 specific activity in various organs Meriones unguiculatus

Storage Stability

EC Number Storage Stability Organism
1.14.13.9 -70°C no loss of enzymatic activity after 24 hours Meriones unguiculatus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.9 L-kynurenine + NADPH + O2
-
 Rattus norvegicus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2
-
 Meriones unguiculatus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2
-
 Rattus norvegicus ? + NADP+
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2 increased activity in injured brain regions following cerebral ischemia Meriones unguiculatus ? + NADP+
-
 ?

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.14.13.9 7 10 50% activity at 7°C and 10°C Meriones unguiculatus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.14.13.9 4
-
 no loss of enzymatic activity after 24 hours Meriones unguiculatus
1.14.13.9 25
-
 22% loss of enzymatic activity after 24 hours Meriones unguiculatus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.9 8 8.5
-
 Meriones unguiculatus