Any feedback?
Literature summary extracted from
- Human corneal aldehyde dehydrogenase: purification, kinetic characterisation and phenotypic variation (1993), Biochem. Mol. Biol. Int., 31, 49-63.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.5 | p-hydroxymercuribenzoate | 0.05 mM | Homo sapiens |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.5 | 0.032 | - |
NAD+ | reaction with benzaldehyde | Homo sapiens | |
| 1.2.1.5 | 0.06 | - |
hexanal | - |
Homo sapiens | |
| 1.2.1.5 | 0.1 | - |
trans-2-hexenal | - |
Homo sapiens | |
| 1.2.1.5 | 0.2 | - |
benzaldehyde | - |
Homo sapiens | |
| 1.2.1.5 | 0.49 | - |
NADP+ | reaction with benzaldehyde | Homo sapiens | |
| 1.2.1.5 | 67 | - |
acetaldehyde | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.5 | additional information | Homo sapiens | enzyme plays a dual role in the absorption of UVR and in the oxidation of peroxidic aldehydes in the mammalian cornea | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.1.5 | Homo sapiens | - |
ALDH3 | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.2.1.5 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.2.1.5 | cornea | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.5 | 46 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.5 | acetaldehyde + NAD+ + H2O | - |
Homo sapiens | acetate + NADH + H+ | - |
? | |
| 1.2.1.5 | benzaldehyde + NAD+ + H2O | - |
Homo sapiens | benzoate + NADH + H+ | - |
? | |
| 1.2.1.5 | benzaldehyde + NADP+ | - |
Homo sapiens | benzoate + NADPH | - |
? | |
| 1.2.1.5 | hexanal + NAD+ + H2O | - |
Homo sapiens | hexanoate + NADH + H+ | - |
? | |
| 1.2.1.5 | malondialdehyde + NAD+ | no activity | Homo sapiens | ? + NADH | - |
? | |
| 1.2.1.5 | additional information | enzyme plays a dual role in the absorption of UVR and in the oxidation of peroxidic aldehydes in the mammalian cornea | Homo sapiens | ? | - |
? | |
| 1.2.1.5 | trans-2-hexenal + NAD+ | - |
Homo sapiens | trans-2-hexenoate + NADH | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.5 | 34 | - |
hexanal | - |
Homo sapiens | |
| 1.2.1.5 | 35.9 | - |
acetaldehyde | - |
Homo sapiens | |
| 1.2.1.5 | 38.8 | - |
NADP+ | reaction with benzaldehyde | Homo sapiens | |
| 1.2.1.5 | 45.3 | - |
NAD+ | reaction with benzaldehyde | Homo sapiens | |
| 1.2.1.5 | 51 | - |
benzaldehyde | - |
Homo sapiens | |
| 1.2.1.5 | 53 | - |
trans-2-hexenal | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
