Literature summary extracted from

Severin, S.E.; Khailova, L.S.; Gomazkova, V.S.
Dehydrogenases of alpha-keto acids: essential groups of the active centers (1986), Adv. Enzyme Regul., 25, 347-375.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.2.1.104	2,3-Butanedione	10 mM, biphasic kinetic, complete inactivation after 20 min	Pigeon
1.2.1.104	5,5'-dithiobis(2-nitrobenzoate)	-	Pigeon
1.2.1.104	diethyldicarbonate	-	Pigeon
1.2.1.104	p-chloromercuribenzoate	0.026 mM, complete inactivation after 80 s	Pigeon
1.2.1.104	Phenylglyoxal	10 mM, biphasic kinetic, complete inactivation after 30 min	Pigeon

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.2.1.104	37000	-	alpha2,beta2, 2 * 42000 + 2 * 37000, SDS-PAGE	Pigeon
1.2.1.104	42000	-	alpha2,beta2, 2 * 42000 + 2 * 37000, SDS-PAGE	Pigeon

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.2.1.104	Pigeon	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.2.1.104	pectoral muscle	-	Pigeon	-

Subunits

EC Number	Subunits	Comment	Organism
1.2.1.104	tetramer	alpha2,beta2, 2 * 42000 + 2 * 37000, SDS-PAGE	Pigeon

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.2.1.104	thiamine diphosphate	two binding sites	Pigeon

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Release 2023.1 (January 2023)