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Literature summary extracted from

  • Campbell, L.L.
    Reductive Degradation of pyrimidines. III. purification and properties of dihydrouracil dehydrogenase (1957), J. Biol. Chem., 227, 693-700.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.1 uracil + NAD(P)H + H+ Clostridium uracilicum reductive pathway of uracil degradation 5,6-dihydrouracil + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.1 Clostridium uracilicum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.1
-
 Clostridium uracilicum

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.1 additional information
-
-
 Clostridium uracilicum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.1 uracil + NAD(P)H + H+ high specificity for uracil Clostridium uracilicum 5,6-dihydrouracil + NAD(P)+
-
 r
1.3.1.1 uracil + NAD(P)H + H+ reductive pathway of uracil degradation Clostridium uracilicum 5,6-dihydrouracil + NAD(P)+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.1 7 7.8 uracil reduction Clostridium uracilicum

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.3.1.1 6.5 8.2 pH 6.5: 33.6% of activity maximum, pH 8.2: 59% of activity maximum Clostridium uracilicum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.1 NADH specific for, no reaction with NADPH Clostridium uracilicum