EC Number | Application | Comment | Organism |
---|---|---|---|
1.3.1.2 | medicine | rate limiting enzyme in catabolic degradation of pyrimidine derivatives, selective inhibition is strategy for design of antitumor, antimicrobial and potentially antiparasitic agents | Sus scrofa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.3.1.2 | cytoplasm | - |
Sus scrofa | 5737 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.2 | Iron | iron atoms are probably present in iron-sulfur centers | Sus scrofa | |
1.3.1.2 | Iron | contains 32 iron atoms per 206000 MW protein | Sus scrofa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.3.1.2 | 107000 | - |
2 * 107000, SDS-PAGE | Sus scrofa |
1.3.1.2 | 206000 | - |
gel filtration | Sus scrofa |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.2 | Sus scrofa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.3.1.2 | - |
Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.1.2 | liver | - |
Sus scrofa | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.3.1.2 | 0.35 | - |
- |
Sus scrofa |
1.3.1.2 | 21 | - |
purified enzyme | Sus scrofa |
EC Number | Storage Stability | Organism |
---|---|---|
1.3.1.2 | -20°C, protein concentration 0.5-1 mg/ml, 1 mM dithiothreitol, stable for several months | Sus scrofa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.2 | 5-aminouracil + NADPH | - |
Sus scrofa | ? | - |
? | |
1.3.1.2 | uracil + NADPH | - |
Sus scrofa | 5,6-dihydrouracil + NADP+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.3.1.2 | dimer | 2 * 107000, SDS-PAGE | Sus scrofa |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.3.1.2 | 37 | - |
assay at | Sus scrofa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.2 | flavin | contains 2 mol FMN and 2 mol FAD per mol of enzyme, tightly associated | Sus scrofa | |
1.3.1.2 | NADPH | - |
Sus scrofa |