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Literature summary extracted from

  • Gil, F.; Pla, A.; Gonzalvo, M.C.; Hernandez, A.F.; Villanueva, E.
    Rat liver paraoxonase: subcellular distribution and characterization (1993), Chem. Biol. Interact., 87, 149-154.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.8.1 Ba2+
-
 Rattus norvegicus
3.1.8.1 Co2+ plasma enzyme more sensitive than liver enzyme Rattus norvegicus
3.1.8.1 Cu2+ plasma enzyme more resistant than liver enzyme Rattus norvegicus
3.1.8.1 EDTA
-
 Rattus norvegicus
3.1.8.1 Hg2+
-
 Rattus norvegicus
3.1.8.1 La3+
-
 Rattus norvegicus
3.1.8.1 Mg2+ plasma enzyme more resistant than liver enzyme Rattus norvegicus
3.1.8.1 Mn2+ plasma enzyme more sensitive than liver enzyme Rattus norvegicus
3.1.8.1 p-hydroxymercuribenzoate
-
 Rattus norvegicus
3.1.8.1 Zn2+ plasma enzyme more resistant than liver enzyme Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.8.1 0.4
-
 paraoxon
-
 Rattus norvegicus
3.1.8.1 0.4
-
 paraoxon 37°C, pH 7.4 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.8.1 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.8.1 Ca2+ requirement Rattus norvegicus
3.1.8.1 Ca2+ required for maximal activity Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.8.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.8.1 two forms, plasma and liver form Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.8.1 blood plasma
-
 Rattus norvegicus
-
3.1.8.1 liver
-
 Rattus norvegicus
-
3.1.8.1 plasma
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
3.1.8.1 -20°C or 4°C, plasma enzyme stable, liver enzyme less stable Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.8.1 paraoxon + H2O
-
 Rattus norvegicus diethylphosphate + 4-nitrophenol
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.8.1 20
-
 plasma enzyme stable, liver enzyme less stable Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.8.1 8.5
-
-
 Rattus norvegicus