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Literature summary extracted from

  • Metrione, R.M.; MacGeorge, N.L.
    The mechanism of action of dipeptidyl aminopeptidase. Inhibition by amino acid derivatives and amines; activation by aromatic compounds (1975), Biochemistry, 14, 5249-5252.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.14.1 phenol activates reaction with Gly-Gly-ethyl ester and Gly-Gly-NH2, no effect on reaction with Gly-Phe-NH2 Bos taurus
3.4.14.1 Pyridine activates reaction with Gly-Gly-ethyl ester and Gly-Gly-NH2, no effect on reaction with Gly-Phe-NH2 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.1 5-aminopentanoic acid ethyl ester
-
 Bos taurus
3.4.14.1 Arg-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
3.4.14.1 benzoyl-Arg-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
3.4.14.1 beta-Ala-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
3.4.14.1 beta-alanine ethyl ester
-
 Bos taurus
3.4.14.1 Butylamine reaction with Gly-Gly-ethyl ester, Gly-Gly-NH2 or Gly-Phe-NH2 Bos taurus
3.4.14.1 ethylamine
-
 Bos taurus
3.4.14.1 gamma-aminobutyryl ethyl ester
-
 Bos taurus
3.4.14.1 Glu-alpha-methyl ester inhibition of the reaction with Gly-Gly-ethyl ester, weak inhibition of reaction with Gly-L-Phe-NH2 Bos taurus
3.4.14.1 Gly-beta-Ala-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
3.4.14.1 Gly-Gly-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
3.4.14.1 Gly-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
3.4.14.1 glycinamide reaction with Gly-Gly-ethyl ester, Gly-Gly-NH2 or Gly-Phe-NH2 Bos taurus
3.4.14.1 glycine ethyl ester
-
 Bos taurus
3.4.14.1 Hexylamine
-
 Bos taurus
3.4.14.1 Leu-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
3.4.14.1 Lys-NH2 inhibition of the reaction with Gly-Gly-ethyl ester, weak inhibition of reaction with Gly-L-Phe-NH2 Bos taurus
3.4.14.1 methylamine
-
 Bos taurus
3.4.14.1 pentylamine
-
 Bos taurus
3.4.14.1 Phe-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
3.4.14.1 Propylamine
-
 Bos taurus
3.4.14.1 Trp-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.1 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.1 spleen
-
 Bos taurus
-