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Literature summary extracted from
- Purification and characterization of an immunoglobulin A1 protease from Bacteroides melaninogenicus (1984), Infect. Immun., 45, 550-557.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.72 | additional information | active only under reducing conditions | Prevotella melaninogenica |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.72 | Traditional protease inhibitors | - |
Prevotella melaninogenica | |
| 3.4.24.13 | 2,2'-dipyridyldisulfide | - |
Prevotella melaninogenica |  |
| 3.4.24.13 | HgCl2 | - |
Prevotella melaninogenica | |
| 3.4.24.13 | iodoacetamide | - |
Prevotella melaninogenica | |
| 3.4.24.13 | p-chloromercuribenzenesulfonic acid | - |
Prevotella melaninogenica | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.72 | 0.0034 | - |
IgA | - |
Prevotella melaninogenica | |
| 3.4.24.13 | 0.0034 | - |
IgA1 | - |
Prevotella melaninogenica |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.72 | 62000 | - |
Bacteroides melaninogenicus | Prevotella melaninogenica |
| 3.4.24.13 | 62000 | - |
gel filtration | Prevotella melaninogenica |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.72 | immunoglobulin A + H2O | Prevotella melaninogenica | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.72 | Prevotella melaninogenica | - |
- |
- |
| 3.4.24.13 | Prevotella melaninogenica | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.72 | - |
Prevotella melaninogenica |
| 3.4.24.13 | - |
Prevotella melaninogenica |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.72 | IgA + H2O | - |
Prevotella melaninogenica | ? | - |
? | |
| 3.4.21.72 | Immunoglobulin A + H2O | cleaves a Pro-Ser bond in the hinge region of the alpha1 chain between residues 223 and 224 | Prevotella melaninogenica | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
| 3.4.21.72 | Immunoglobulin A + H2O | specific for human immunoglobulin IgA1 | Prevotella melaninogenica | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
| 3.4.21.72 | immunoglobulin A + H2O | - |
Prevotella melaninogenica | ? | - |
? | |
| 3.4.24.13 | IgA1 + H2O | - |
Prevotella melaninogenica | ? | - |
? | |
| 3.4.24.13 | immunoglobulin A1 + H2O | specific for human IgA1 | Prevotella melaninogenica | oligopeptides derived from immunoglobulin A1 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.24.13 | monomer | 1 * 62000, SDS-PAGE | Prevotella melaninogenica |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.72 | additional information | - |
pI: 5.0 | Prevotella melaninogenica |
| 3.4.21.72 | 5 | - |
- |
Prevotella melaninogenica |
| 3.4.24.13 | 5 | - |
- |
Prevotella melaninogenica |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.13 | 4.5 | 7.5 | active over the range pH 4.5-7.5 | Prevotella melaninogenica |
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