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Literature summary extracted from

  • Croteau, R.; Alonso, W.R.; Koepp, A.E.; Shim, J.H.; Cane, D.E.
    Irreversible inactivation of monoterpene cyclases by a mechanism-based inhibitor (1993), Arch. Biochem. Biophys., 307, 397-404.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.3.16 6-cyclopropylidene-(3E)-methyl-hex-2-en-1-yl diphosphate Ki: 0.0003 mM, irreversible covalent modification Mentha sp.
4.2.3.16 diethyl dicarbonate
-
 Mentha sp.
4.2.3.16 p-hydroxymercuribenzoate
-
 Mentha sp.
5.5.1.8 6-cyclopropylidene-(3E)-methyl-hex-2-en-1-yl diphosphate about 50% inhibition at 0.01 mM for 20 min Salvia officinalis
5.5.1.8 6-cyclopropylidene-(3E)-methyl-hex-2-en-1-yl diphosphate about 50% inhibition at 0.01 mM for 20 min Tanacetum vulgare

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.16 geranyl diphosphate Mentha sp.
-
 (-)-(4S)-limonene + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.16 Mentha sp.
-
 M. spicata
-
5.5.1.8 Salvia officinalis
-
-
-
5.5.1.8 Tanacetum vulgare
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.3.16 leaf glandular trichome secretory cells Mentha sp.
-
5.5.1.8 leaf
-
 Salvia officinalis
-
5.5.1.8 leaf
-
 Tanacetum vulgare
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.16 geranyl diphosphate
-
 Mentha sp. (-)-(4S)-limonene + diphosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.3.16 0.0003
-
 6-cyclopropylidene-(3E)-methyl-hex-2-en-1-yl diphosphate irreversible covalent modification Mentha sp.