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Literature summary extracted from

  • Foreman, J.E.; Niehaus, W.G.
    Zn2+-induced cooperativity of mannitol-1-phosphate dehydrogenase from Aspergillus parasiticus (1985), J. Biol. Chem., 260, 10019-10022.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.17 Cd2+ competitive inhibition Aspergillus niger
1.1.1.17 Cd2+ cooperative binding Aspergillus parasiticus
1.1.1.17 Co2+ competitive inhibition Aspergillus niger
1.1.1.17 Co2+ cooperative binding Aspergillus parasiticus
1.1.1.17 Cu2+ irreversible inactivation Aspergillus niger
1.1.1.17 Cu2+ irreversible inactivation Aspergillus parasiticus
1.1.1.17 Hg2+ irreversible inactivation Aspergillus niger
1.1.1.17 Hg2+ irreversible inactivation Aspergillus parasiticus
1.1.1.17 Ni2+ competitive inhibition Aspergillus niger
1.1.1.17 Ni2+ cooperative binding Aspergillus parasiticus
1.1.1.17 Zn2+ competitive with respect to D-fructose 6-phosphate, noncompetitive inhibition with respect to NADH Aspergillus niger
1.1.1.17 Zn2+ cooperative binding of Zn2+, competitive type if KCl concentration is greater 100 mM, sigmoidal type at lower salt concentrations Aspergillus parasiticus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.17 intracellular
-
 Aspergillus niger 5622
-
1.1.1.17 intracellular
-
 Aspergillus parasiticus 5622
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.17 40000
-
 gel filtration Aspergillus niger
1.1.1.17 40000
-
 gel filtration Aspergillus parasiticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.17 D-mannitol 1-phosphate + NAD+ Aspergillus niger
-
 D-fructose 6-phosphate + NADH + H+
-
 r
1.1.1.17 D-mannitol 1-phosphate + NAD+ Aspergillus parasiticus
-
 D-fructose 6-phosphate + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.17 Aspergillus niger
-
-
-
1.1.1.17 Aspergillus parasiticus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.17 to homogeneity, chromatography techniques Aspergillus niger
1.1.1.17 to homogeneity, chromatography techniques Aspergillus parasiticus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.17 cell culture
-
 Aspergillus niger
-
1.1.1.17 cell culture
-
 Aspergillus parasiticus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.17 150
-
-
 Aspergillus niger
1.1.1.17 190
-
-
 Aspergillus parasiticus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.17 D-mannitol 1-phosphate + NAD+
-
 Aspergillus niger D-fructose 6-phosphate + NADH + H+
-
 r
1.1.1.17 D-mannitol 1-phosphate + NAD+
-
 Aspergillus parasiticus D-fructose 6-phosphate + NADH + H+
-
 r

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.17 30
-
 half-life: 2 h, decreasing stability in the presence of zinc ions Aspergillus parasiticus
1.1.1.17 30
-
 half-life: above 280 min Aspergillus niger

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.17 NAD+
-
 Aspergillus niger
1.1.1.17 NAD+
-
 Aspergillus parasiticus
1.1.1.17 NADH
-
 Aspergillus niger
1.1.1.17 NADH
-
 Aspergillus parasiticus