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Literature summary extracted from

  • Nair, P.M.
    Regulation of nuclear 3-hydroxyanthranilic acid oxidase by guanine (1972), Arch. Biochem. Biophys., 153, 139-146.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.3.5 adenine
-
 Gallus sp.
1.10.3.5 adenine
-
 Mus musculus
1.10.3.5 adenine
-
 Ovis aries
1.10.3.5 adenine
-
 Rattus norvegicus
1.10.3.5 ATP 8% inhibition Rattus norvegicus
1.10.3.5 CTP 16% inhibition Rattus norvegicus
1.10.3.5 cytosine
-
 Gallus sp.
1.10.3.5 cytosine
-
 Mus musculus
1.10.3.5 cytosine
-
 Ovis aries
1.10.3.5 cytosine
-
 Rattus norvegicus
1.10.3.5 dATP 4% inhibition Rattus norvegicus
1.10.3.5 dCTP 20% inhibition Rattus norvegicus
1.10.3.5 dGTP 24% inhibition Rattus norvegicus
1.10.3.5 GTP 20% inhibition Rattus norvegicus
1.10.3.5 guanine
-
 Gallus sp.
1.10.3.5 guanine
-
 Mus musculus
1.10.3.5 guanine
-
 Ovis aries
1.10.3.5 guanine
-
 Rattus norvegicus
1.10.3.5 Uracil
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.10.3.5 3-hydroxyanthranilic acid + O2 Spinacia oleracea
-
 2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2 cinnabarinic acid, oxidative dimerization ?
1.10.3.5 3-hydroxyanthranilic acid + O2 Streptomyces antibioticus
-
 2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2 cinnabarinic acid, oxidative dimerization ?
1.10.3.5 3-hydroxyanthranilic acid + O2 Trametes coccinea
-
 2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2 cinnabarinic acid, oxidative dimerization ?

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.5 Gallus sp.
-
 chicken
-
1.10.3.5 Mus musculus
-
 mouse, Swiss mice
-
1.10.3.5 Ovis aries
-
 sheep
-
1.10.3.5 Rattus norvegicus
-
-
-
1.10.3.5 Spinacia oleracea
-
 spinach
-
1.10.3.5 Streptomyces antibioticus
-
-
-
1.10.3.5 Trametes coccinea
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.10.3.5 kidney
-
 Rattus norvegicus
-
1.10.3.5 leaf
-
 Spinacia oleracea
-
1.10.3.5 liver
-
 Mus musculus
-
1.10.3.5 liver
-
 Rattus norvegicus
-
1.10.3.5 liver
-
 Ovis aries
-
1.10.3.5 liver
-
 Gallus sp.
-
1.10.3.5 spleen
-
 Rattus norvegicus
-
1.10.3.5 thymus
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.10.3.5 0.03
-
 thymus tissue, 0.008 M substrate Rattus norvegicus
1.10.3.5 0.034
-
 thymus tissue, 0.001 M substrate Rattus norvegicus
1.10.3.5 0.037
-
 spleen tissue, 0.001 M substrate Rattus norvegicus
1.10.3.5 0.047
-
 thymus tissue, 0.004 M substrate Rattus norvegicus
1.10.3.5 0.07
-
 regenerating liver Rattus norvegicus
1.10.3.5 0.134
-
 kidney tissue, 0.001 M substrate Rattus norvegicus
1.10.3.5 0.16
-
-
 Mus musculus
1.10.3.5 0.185
-
-
 Gallus sp.
1.10.3.5 0.212
-
 female Rattus norvegicus
1.10.3.5 0.24
-
-
 Ovis aries
1.10.3.5 0.25
-
 liver tissue Rattus norvegicus
1.10.3.5 0.264
-
 male Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Mus musculus 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Rattus norvegicus 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Ovis aries 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Spinacia oleracea 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Streptomyces antibioticus 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Gallus sp. 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Trametes coccinea 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 3-hydroxyanthranilic acid + O2
-
 Spinacia oleracea 2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2 cinnabarinic acid, oxidative dimerization ?
1.10.3.5 3-hydroxyanthranilic acid + O2
-
 Streptomyces antibioticus 2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2 cinnabarinic acid, oxidative dimerization ?
1.10.3.5 3-hydroxyanthranilic acid + O2
-
 Trametes coccinea 2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2 cinnabarinic acid, oxidative dimerization ?