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Literature summary extracted from

  • Fischer, R.; Jensen, R.
    Prephenate dehydrogenase (monofunctional) (1987), Methods Enzymol., 142, 503-507.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.12 4-hydroxyphenylpyruvate
-
 Bacillus subtilis
1.3.1.12 4-hydroxyphenylpyruvate
-
 Cupriavidus necator
1.3.1.12 chorismate
-
 Bacillus subtilis
1.3.1.12 L-phenylalanine
-
 Bacillus subtilis
1.3.1.12 L-tryptophan
-
 Bacillus subtilis
1.3.1.12 L-tyrosine
-
 Bacillus subtilis
1.3.1.12 L-tyrosine
-
 Cupriavidus necator

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.12 0.045 0.09 prephenate
-
 Cupriavidus necator
1.3.1.12 0.045 0.09 prephenate
-
 Xanthomonas campestris
1.3.1.12 2
-
 prephenate
-
 Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.12 prephenate + NAD+ Bacillus subtilis biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ Cupriavidus necator biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ Xanthomonas campestris biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.12 Bacillus subtilis
-
-
-
1.3.1.12 Cupriavidus necator
-
 basonym Alcaligenes eutrophus
-
1.3.1.12 Xanthomonas campestris
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.12
-
 Cupriavidus necator

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.12 8.9
-
-
 Cupriavidus necator

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.12 prephenate + NAD+
-
 Bacillus subtilis 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+
-
 Cupriavidus necator 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+
-
 Xanthomonas campestris 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ biosynthesis of L-tyrosine Bacillus subtilis 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ biosynthesis of L-tyrosine Cupriavidus necator 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ biosynthesis of L-tyrosine Xanthomonas campestris 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.12 NAD+
-
 Bacillus subtilis
1.3.1.12 NAD+
-
 Xanthomonas campestris