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Literature summary extracted from

  • Koch, G.L.E.; Shaw, D.C.; Gibson, F.
    Studies on the relationship between the active sites of chorismate mutase-prephenate dehydrogenase from Escherichia coli or Aerobacter aerogenes (1972), Biochim. Biophys. Acta, 258, 719-730.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.12 iodoacetamide modification of only one cysteinyl residue results in the inactivation Escherichia coli
1.3.1.12 iodoacetamide
-
 Klebsiella aerogenes
1.3.1.12 iodoacetate
-
 Escherichia coli
1.3.1.12 iodoacetate
-
 Klebsiella aerogenes
1.3.1.12 N-bromosuccinimide
-
 Escherichia coli
1.3.1.12 N-ethylmaleimide
-
 Escherichia coli
1.3.1.12 Tetranitromethane
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.12 0.35 0.37 prephenate
-
 Escherichia coli
1.3.1.12 0.35 0.37 prephenate
-
 Klebsiella aerogenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.12 prephenate + NAD+ Escherichia coli biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ Klebsiella aerogenes biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.12 Escherichia coli
-
-
-
1.3.1.12 Klebsiella aerogenes
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.12 additional information
-
-
 Escherichia coli
1.3.1.12 additional information
-
-
 Klebsiella aerogenes

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.12 prephenate + NAD+
-
 Escherichia coli 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+
-
 Klebsiella aerogenes 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ biosynthesis of L-tyrosine Escherichia coli 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ biosynthesis of L-tyrosine Klebsiella aerogenes 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.12 chorismate mutase-prephenate dehydrogenase bifunctional enzyme complex with EC 5.4.99.5 Escherichia coli
1.3.1.12 chorismate mutase-prephenate dehydrogenase bifunctional enzyme complex with EC 5.4.99.5 Klebsiella aerogenes