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Literature summary extracted from
- Kinetic studies on the reactions catalyzed by chorismate mutase-prephenate dehydrogenase from Aerobacter aerogenes (1978), Biochemistry, 17, 1573-1580.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.12 | bovine serum albumin | - |
Klebsiella aerogenes |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.3.1.12 | glycerol stabilizes | Klebsiella aerogenes |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.12 | 4-hydroxyphenylpyruvate | - |
Klebsiella aerogenes |  |
| 1.3.1.12 | AMP | - |
Klebsiella aerogenes | |
| 1.3.1.12 | additional information | substrate analogues | Klebsiella aerogenes | |
| 1.3.1.12 | NADH | - |
Klebsiella aerogenes | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.12 | prephenate + NAD+ | Klebsiella aerogenes | biosynthesis of L-tyrosine | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
ir | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.12 | Klebsiella aerogenes | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.3.1.12 | chorismate mutase-prephenate dehydrogenase bifunctional enzyme | Klebsiella aerogenes |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.12 | 33 | - |
chorismate mutase-prephenate dehydrogenase bifunctional enzyme | Klebsiella aerogenes |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.3.1.12 | -15°C, 0.02% sodium azide, N2-atmosphere, more than 0.1 mg/ml protein | Klebsiella aerogenes |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.12 | prephenate + NAD+ | mechanism, kinetic studies | Klebsiella aerogenes | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
ir | |
| 1.3.1.12 | prephenate + NAD+ | biosynthesis of L-tyrosine | Klebsiella aerogenes | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
ir | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.1.12 | chorismate mutase-prephenate dehydrogenase bifunctional enzyme | complex with EC 5.4.99.5 | Klebsiella aerogenes |
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Release 2023.1 (January 2023)
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