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Literature summary extracted from

  • Byng, G.S.; Berry, A.; Jensen, R.A.
    Evolutionary implications of features of aromatic amino acid biosynthesis in the genus Acinetobacter (1985), Arch. Microbiol., 143, 122-129.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.13 L-tyrosine competitive inhibition with respect to substrate and noncompetitively with respect to cofactor Acinetobacter calcoaceticus
1.3.1.13 NADP+
-
 Acinetobacter calcoaceticus
1.3.1.78 L-tyrosine competitive inhibition Acinetobacter calcoaceticus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.13 0.005
-
 NADP+
-
 Acinetobacter calcoaceticus
1.3.1.13 0.033
-
 prephenate
-
 Acinetobacter calcoaceticus
1.3.1.78 0.005
-
 NADP+ ATCC 23055 Acinetobacter calcoaceticus
1.3.1.78 0.313
-
 L-arogenate ATCC 23055 Acinetobacter calcoaceticus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.13 210000
-
 gel filtration Acinetobacter calcoaceticus
1.3.1.78 210000
-
 ATCC 23055, gel filtration Acinetobacter calcoaceticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.13 prephenate + NADP+ Acinetobacter calcoaceticus
-
 4-hydroxyphenylpyruvate + CO2 + NADPH
-
 ?
1.3.1.13 prephenate + NADP+ Acinetobacter sp.
-
 4-hydroxyphenylpyruvate + CO2 + NADPH
-
 ?
1.3.1.13 prephenate + NADP+ Acinetobacter lwoffii
-
 4-hydroxyphenylpyruvate + CO2 + NADPH
-
 ?
1.3.1.13 prephenate + NADP+ Acinetobacter sp. C1W
-
 4-hydroxyphenylpyruvate + CO2 + NADPH
-
 ?
1.3.1.78 L-arogenate + NAD+ Acinetobacter calcoaceticus
-
 L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+ Acinetobacter sp.
-
 L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+ Acinetobacter lwoffii
-
 L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+ Acinetobacter sp. C1W
-
 L-tyrosine + NADH + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.13 Acinetobacter calcoaceticus
-
 ATCC 14987
-
1.3.1.13 Acinetobacter calcoaceticus
-
 ATCC 23055
-
1.3.1.13 Acinetobacter lwoffii
-
 ATCC 15309
-
1.3.1.13 Acinetobacter sp.
-
-
-
1.3.1.13 Acinetobacter sp. C1W
-
-
-
1.3.1.78 Acinetobacter calcoaceticus
-
 ATCC 23055 and ATCC 14987
-
1.3.1.78 Acinetobacter lwoffii
-
 ATCC 15309
-
1.3.1.78 Acinetobacter sp.
-
-
-
1.3.1.78 Acinetobacter sp. C1W
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.13 strain 23055, partially Acinetobacter calcoaceticus
1.3.1.78 ATCC 23055, partial Acinetobacter calcoaceticus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.78 0.0021
-
-
 Acinetobacter sp.
1.3.1.78 0.0039
-
 ATCC 23055 Acinetobacter calcoaceticus
1.3.1.78 0.0043
-
 ATCC 14987 Acinetobacter calcoaceticus
1.3.1.78 0.0063
-
-
 Acinetobacter lwoffii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.13 prephenate + NADP+
-
 Acinetobacter calcoaceticus 4-hydroxyphenylpyruvate + CO2 + NADPH
-
 ?
1.3.1.13 prephenate + NADP+
-
 Acinetobacter sp. 4-hydroxyphenylpyruvate + CO2 + NADPH
-
 ?
1.3.1.13 prephenate + NADP+
-
 Acinetobacter lwoffii 4-hydroxyphenylpyruvate + CO2 + NADPH
-
 ?
1.3.1.13 prephenate + NADP+
-
 Acinetobacter sp. C1W 4-hydroxyphenylpyruvate + CO2 + NADPH
-
 ?
1.3.1.78 L-arogenate + NAD(P)+
-
 Acinetobacter calcoaceticus L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.78 L-arogenate + NAD(P)+
-
 Acinetobacter sp. L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.78 L-arogenate + NAD(P)+
-
 Acinetobacter lwoffii L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.78 L-arogenate + NAD(P)+
-
 Acinetobacter sp. C1W L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+
-
 Acinetobacter calcoaceticus L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+
-
 Acinetobacter sp. L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+
-
 Acinetobacter lwoffii L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+
-
 Acinetobacter sp. C1W L-tyrosine + NADH + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.13 NADP+
-
 Acinetobacter calcoaceticus
1.3.1.78 NADP+
-
 Acinetobacter calcoaceticus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.13 0.009
-
 L-tyrosine competitive inhibition with respect to substrate and noncompetitively with respect to cofactor Acinetobacter calcoaceticus
1.3.1.13 0.038
-
 NADP+
-
 Acinetobacter calcoaceticus
1.3.1.78 0.009
-
 L-tyrosine ATCC 23055, competitive inhibition Acinetobacter calcoaceticus